FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024496412> ?p ?o ?g. }

• W2024496412 endingPage "1917" @default.
• W2024496412 startingPage "1909" @default.
• W2024496412 abstract "It is well known that cyclic mechanical loading can produce an anabolic response in bone. In vivo studies have shown that the insertion of short-term recovery periods (10-15 s) into mechanical loading profiles led to an increased osteogenic response compared to continuous cyclic loading of bone. Although this is suggestive of temporal processing at the bone cell level, there is little evidence to support such a hypothesis. Therefore, the current study investigated the cellular mechanism of bone's response to rest inserted vs. continuous mechanical loading. Cell responses to rest inserted mechanical loading were quantified by applying oscillatory fluid flow (OFF) to osteoblastic cells and quantifying real-time intracellular calcium [Ca2+]i, prostaglandin E2 (PGE2) release, and osteopontin (OPN) mRNA levels. Cells were exposed to OFF (1 Hz) at shear stresses of 1 and 2 Pa with rest periods of 5, 10, and 15s inserted every 10 loading cycles. The insertion of 10 and 15s rest periods into the flow profile resulted in multiple [Ca2+]i responses by individual cells, increased [Ca2+]i response magnitudes, and increased overall percent of cells responding compared to continuously loaded control groups. We determined the source of the multiple calcium responses to be from intracellular stores. In addition, rest inserted OFF led to similar levels of PGE2 release and increased levels of relative OPN mRNA compared to cells exposed to continuous OFF. Our study suggests that the cellular mechanism of bone adaptation to rest inserted mechanical loading may involve modulation of intracellular levels of calcium (frequency, magnitude, percent of cells responding)." @default.
• W2024496412 created "2016-06-24" @default.
• W2024496412 creator A5058617281 @default.
• W2024496412 creator A5060241503 @default.
• W2024496412 creator A5069686409 @default.
• W2024496412 creator A5072227102 @default.
• W2024496412 creator A5076638994 @default.
• W2024496412 creator A5080883469 @default.
• W2024496412 creator A5086137850 @default.
• W2024496412 date "2005-09-01" @default.
• W2024496412 modified "2023-10-16" @default.
• W2024496412 title "Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells" @default.
• W2024496412 cites W1486376581 @default.
• W2024496412 cites W1510877630 @default.
• W2024496412 cites W1638542927 @default.
• W2024496412 cites W1650401181 @default.
• W2024496412 cites W1666469474 @default.
• W2024496412 cites W1784820495 @default.
• W2024496412 cites W1918886276 @default.
• W2024496412 cites W1930917734 @default.
• W2024496412 cites W1964449421 @default.
• W2024496412 cites W1965021019 @default.
• W2024496412 cites W1971690617 @default.
• W2024496412 cites W1976300411 @default.
• W2024496412 cites W1982267750 @default.
• W2024496412 cites W2002441736 @default.
• W2024496412 cites W2007438632 @default.
• W2024496412 cites W2007720628 @default.
• W2024496412 cites W2012388796 @default.
• W2024496412 cites W2019717438 @default.
• W2024496412 cites W2026884931 @default.
• W2024496412 cites W2027946603 @default.
• W2024496412 cites W2036338634 @default.
• W2024496412 cites W2040882780 @default.
• W2024496412 cites W2042408524 @default.
• W2024496412 cites W2044691550 @default.
• W2024496412 cites W2048314987 @default.
• W2024496412 cites W2050895304 @default.
• W2024496412 cites W2055407120 @default.
• W2024496412 cites W2058848868 @default.
• W2024496412 cites W2063553561 @default.
• W2024496412 cites W2069613012 @default.
• W2024496412 cites W2071601513 @default.
• W2024496412 cites W2075355171 @default.
• W2024496412 cites W2076464772 @default.
• W2024496412 cites W2088602091 @default.
• W2024496412 cites W2114495080 @default.
• W2024496412 cites W2129725829 @default.
• W2024496412 cites W2135011583 @default.
• W2024496412 cites W2145937652 @default.
• W2024496412 cites W2155937147 @default.
• W2024496412 cites W2261772264 @default.
• W2024496412 cites W4249759827 @default.
• W2024496412 cites W4376453153 @default.
• W2024496412 doi "https://doi.org/10.1016/j.jbiomech.2004.08.009" @default.
• W2024496412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16023480" @default.
• W2024496412 hasPublicationYear "2005" @default.
• W2024496412 type Work @default.
• W2024496412 sameAs 2024496412 @default.
• W2024496412 citedByCount "122" @default.
• W2024496412 countsByYear W20244964122012 @default.
• W2024496412 countsByYear W20244964122013 @default.
• W2024496412 countsByYear W20244964122014 @default.
• W2024496412 countsByYear W20244964122015 @default.
• W2024496412 countsByYear W20244964122016 @default.
• W2024496412 countsByYear W20244964122017 @default.
• W2024496412 countsByYear W20244964122018 @default.
• W2024496412 countsByYear W20244964122019 @default.
• W2024496412 countsByYear W20244964122020 @default.
• W2024496412 countsByYear W20244964122021 @default.
• W2024496412 countsByYear W20244964122022 @default.
• W2024496412 countsByYear W20244964122023 @default.
• W2024496412 crossrefType "journal-article" @default.
• W2024496412 hasAuthorship W2024496412A5058617281 @default.
• W2024496412 hasAuthorship W2024496412A5060241503 @default.
• W2024496412 hasAuthorship W2024496412A5069686409 @default.
• W2024496412 hasAuthorship W2024496412A5072227102 @default.
• W2024496412 hasAuthorship W2024496412A5076638994 @default.
• W2024496412 hasAuthorship W2024496412A5080883469 @default.
• W2024496412 hasAuthorship W2024496412A5086137850 @default.
• W2024496412 hasConcept C1008401 @default.
• W2024496412 hasConcept C12554922 @default.
• W2024496412 hasConcept C126322002 @default.
• W2024496412 hasConcept C133605539 @default.
• W2024496412 hasConcept C134018914 @default.
• W2024496412 hasConcept C181080969 @default.
• W2024496412 hasConcept C185592680 @default.
• W2024496412 hasConcept C2777956040 @default.
• W2024496412 hasConcept C2780804394 @default.
• W2024496412 hasConcept C519063684 @default.
• W2024496412 hasConcept C55493867 @default.
• W2024496412 hasConcept C71924100 @default.
• W2024496412 hasConcept C77265313 @default.
• W2024496412 hasConcept C79879829 @default.
• W2024496412 hasConcept C86803240 @default.
• W2024496412 hasConcept C95444343 @default.
• W2024496412 hasConceptScore W2024496412C1008401 @default.
• W2024496412 hasConceptScore W2024496412C12554922 @default.

• next