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• W2024497005 abstract "A cytological study has been made on HeLa cells infected with herpes virus. Two types of specific cellular lesion were recognized: (1) the classic lesions of interphase cells and (2) a lesion of mitosis which rapidly replaces normal mitotic cells and which has a transitory existence only. The results suggest that inhibition of cell division by this virus is characterized either (a) by failure to enter mitosis or (b) by an abnormal mitosis. Microspectrophotometry of Feulgen-stained preparations confirmed that, after a lag period, there is a net increase of the DNA per nucleus in infected cells. At the same time autoradiography has shown that the rate of incorporation of tritiated thymidine is depressed. This paradox may be partly explained if the intracellular deoxyribonucleotide concentration is increased after infection. One factor contributing to such an increase could be breakdown of host nucleic acid as a result of infection. Studies on the loss of label from cells preincubated with tritiated thymidine suggest that such a breakdown may occur." @default.
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• W2024497005 date "1961-12-01" @default.
• W2024497005 modified "2023-09-30" @default.
• W2024497005 title "Quantitative cytological studies on Hela cells infected with herpes virus" @default.
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• W2024497005 doi "https://doi.org/10.1016/0042-6822(61)90115-5" @default.
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