FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024500566> ?p ?o ?g. }

• W2024500566 endingPage "5191" @default.
• W2024500566 startingPage "5191" @default.
• W2024500566 abstract "Pericytes, the vascular cells that constitute the outer layer of capillaries, have been shown to have a crucial role in vascular development and stability. Loss of pericytes precedes endothelial cell dysfunction and vascular degeneration in small-vessel diseases, including diabetic retinopathy. Despite their clinical relevance, the cellular pathways controlling survival of retinal pericytes remain largely uncharacterized. Therefore, we investigated the role of Notch signaling, a master regulator of cell fate decisions, in retinal pericyte survival.A coculture system of ligand-dependent Notch signaling was developed using primary cultured retinal pericytes and a mesenchymal cell line derived from an inducible mouse model expressing the Delta-like 1 Notch ligand. This model was used to examine the effect of Notch activity on pericyte survival using quantitative PCR (qPCR) and a light-induced cell death assay. The effect of Notch gain- and loss-of-function was analyzed in monocultures of retinal pericytes using antibody arrays to interrogate the expression of apoptosis-related proteins.Primary cultured retinal pericytes differentially expressed key molecules of the Notch pathway and displayed strong expression of canonical Notch/RBPJK (recombination signal-binding protein 1 for J-kappa) downstream targets. A gene expression screen using gain- and loss-of-function approaches identified genes relevant to cell survival as downstream targets of Notch activity in retinal pericytes. Ligand-mediated Notch activity protected retinal pericytes from light-induced cell death.Our results have identified signature genes downstream of Notch activity in retinal pericytes and suggest that tight regulation of Notch signaling is crucial for pericyte survival." @default.
• W2024500566 created "2016-06-24" @default.
• W2024500566 creator A5000073854 @default.
• W2024500566 creator A5057118141 @default.
• W2024500566 creator A5063077617 @default.
• W2024500566 creator A5084162330 @default.
• W2024500566 creator A5086530950 @default.
• W2024500566 creator A5086936371 @default.
• W2024500566 date "2014-08-20" @default.
• W2024500566 modified "2023-10-14" @default.
• W2024500566 title "Notch Signaling Functions in Retinal Pericyte Survival" @default.
• W2024500566 cites W1244702794 @default.
• W2024500566 cites W1504123405 @default.
• W2024500566 cites W1584607924 @default.
• W2024500566 cites W1691160266 @default.
• W2024500566 cites W1956254370 @default.
• W2024500566 cites W1973418567 @default.
• W2024500566 cites W1977514835 @default.
• W2024500566 cites W1977962361 @default.
• W2024500566 cites W1981497203 @default.
• W2024500566 cites W1985657116 @default.
• W2024500566 cites W1989036458 @default.
• W2024500566 cites W2002979159 @default.
• W2024500566 cites W2009027924 @default.
• W2024500566 cites W2021556801 @default.
• W2024500566 cites W2022502270 @default.
• W2024500566 cites W2029399003 @default.
• W2024500566 cites W2036540072 @default.
• W2024500566 cites W2047578520 @default.
• W2024500566 cites W2048447073 @default.
• W2024500566 cites W2052882363 @default.
• W2024500566 cites W2054833717 @default.
• W2024500566 cites W2062558128 @default.
• W2024500566 cites W2067489256 @default.
• W2024500566 cites W2073465941 @default.
• W2024500566 cites W2078767245 @default.
• W2024500566 cites W2082363445 @default.
• W2024500566 cites W2083800064 @default.
• W2024500566 cites W2085945159 @default.
• W2024500566 cites W2086918224 @default.
• W2024500566 cites W2090538603 @default.
• W2024500566 cites W2092671785 @default.
• W2024500566 cites W2101172768 @default.
• W2024500566 cites W2103046899 @default.
• W2024500566 cites W2108337314 @default.
• W2024500566 cites W2115181518 @default.
• W2024500566 cites W2115390024 @default.
• W2024500566 cites W2119296327 @default.
• W2024500566 cites W2119677723 @default.
• W2024500566 cites W2123478725 @default.
• W2024500566 cites W2125302698 @default.
• W2024500566 cites W2125846791 @default.
• W2024500566 cites W2131581981 @default.
• W2024500566 cites W2147298899 @default.
• W2024500566 cites W2147435977 @default.
• W2024500566 cites W2149152049 @default.
• W2024500566 cites W2153186684 @default.
• W2024500566 cites W2154671188 @default.
• W2024500566 cites W2156606731 @default.
• W2024500566 cites W2158250531 @default.
• W2024500566 cites W2159061573 @default.
• W2024500566 cites W2162097271 @default.
• W2024500566 cites W2164849887 @default.
• W2024500566 cites W2168420558 @default.
• W2024500566 cites W2169413646 @default.
• W2024500566 cites W2169926171 @default.
• W2024500566 cites W241669560 @default.
• W2024500566 cites W2483951904 @default.
• W2024500566 cites W2585792739 @default.
• W2024500566 cites W3099514962 @default.
• W2024500566 doi "https://doi.org/10.1167/iovs.14-14046" @default.
• W2024500566 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4139112" @default.
• W2024500566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25015359" @default.
• W2024500566 hasPublicationYear "2014" @default.
• W2024500566 type Work @default.
• W2024500566 sameAs 2024500566 @default.
• W2024500566 citedByCount "22" @default.
• W2024500566 countsByYear W20245005662015 @default.
• W2024500566 countsByYear W20245005662016 @default.
• W2024500566 countsByYear W20245005662017 @default.
• W2024500566 countsByYear W20245005662018 @default.
• W2024500566 countsByYear W20245005662019 @default.
• W2024500566 countsByYear W20245005662020 @default.
• W2024500566 countsByYear W20245005662021 @default.
• W2024500566 countsByYear W20245005662022 @default.
• W2024500566 countsByYear W20245005662023 @default.
• W2024500566 crossrefType "journal-article" @default.
• W2024500566 hasAuthorship W2024500566A5000073854 @default.
• W2024500566 hasAuthorship W2024500566A5057118141 @default.
• W2024500566 hasAuthorship W2024500566A5063077617 @default.
• W2024500566 hasAuthorship W2024500566A5084162330 @default.
• W2024500566 hasAuthorship W2024500566A5086530950 @default.
• W2024500566 hasAuthorship W2024500566A5086936371 @default.
• W2024500566 hasBestOaLocation W20245005661 @default.
• W2024500566 hasConcept C111758988 @default.
• W2024500566 hasConcept C123012128 @default.
• W2024500566 hasConcept C161879069 @default.
• W2024500566 hasConcept C169760540 @default.

• next