FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024505897> ?p ?o ?g. }

• W2024505897 endingPage "700" @default.
• W2024505897 startingPage "690" @default.
• W2024505897 abstract "The cardiac natriuretic peptide family includes atrial natriuretic factor and brain or B-type natriuretic peptide, also known as iso-atrial natriuretic factor (isoANF). Although these peptides contribute to cardiovascular homeostasis, their respective roles remain unclear. To study regulation of atrial natriuretic factor and isoANF gene expression during progression of hypertension, we developed a quantitative polymerase chain reaction protocol to measure their transcript level in spontaneously hypertensive rat (SHR) hearts. At the onset of hypertension, atrial natriuretic factor transcripts in 5-week-old SHR were 50% of those of age-matched Wistar-Kyoto (WKY) rats, whereas the level of isoANF transcripts was similar in atria and twofold higher in ventricles. Because atria are the major sites of atrial natriuretic factor gene expression and ventricles contribute predominantly to cardiac isoANF synthesis, total atrial natriuretic factor messenger RNA (mRNA) in the hearts of 5-week-old SHR was about 50% of that in WKY rats, and total isoANF mRNA content was already higher than in control rats. In left ventricles and ventricular septa, progression of hypertension led to a maximal increase of twofold and fourfold in atrial natriuretic factor and isoANF mRNA levels, respectively, with no detectable change in right ventricles. In the atria of older SHR, atrial natriuretic factor and isoANF mRNA levels were comparable to those of age-matched controls. These data indicate that, although increased blood pressure stimulates both atrial natriuretic factor and isoANF gene expression, regulation of the two natriuretic peptide genes is not temporally coordinated in all cardiac compartments. Furthermore, isoANF mRNA is already induced in the ventricles at the onset of the hypertensive stage, and in older SHR, the isoANF gene is hyperresponsive to progression of hypertension compared with atrial natriuretic factor. Thus, isoANF might represent a very sensitive marker of cardiac changes in hypertension." @default.
• W2024505897 created "2016-06-24" @default.
• W2024505897 creator A5004454600 @default.
• W2024505897 creator A5012918619 @default.
• W2024505897 creator A5086029201 @default.
• W2024505897 date "1992-11-01" @default.
• W2024505897 modified "2023-10-15" @default.
• W2024505897 title "Increased transcripts for B-type natriuretic peptide in spontaneously hypertensive rats. Quantitative polymerase chain reaction for atrial and brain natriuretic peptide transcripts." @default.
• W2024505897 cites W1546454746 @default.
• W2024505897 cites W1559091327 @default.
• W2024505897 cites W1905627889 @default.
• W2024505897 cites W1977859154 @default.
• W2024505897 cites W1980929921 @default.
• W2024505897 cites W1981438457 @default.
• W2024505897 cites W1986819632 @default.
• W2024505897 cites W1993202191 @default.
• W2024505897 cites W1995787496 @default.
• W2024505897 cites W1998329969 @default.
• W2024505897 cites W1999786342 @default.
• W2024505897 cites W2016377224 @default.
• W2024505897 cites W2049664335 @default.
• W2024505897 cites W2052097767 @default.
• W2024505897 cites W2052248858 @default.
• W2024505897 cites W2054423282 @default.
• W2024505897 cites W2108311279 @default.
• W2024505897 cites W2123600602 @default.
• W2024505897 cites W2145551489 @default.
• W2024505897 cites W2155500010 @default.
• W2024505897 cites W2158841946 @default.
• W2024505897 cites W2162804111 @default.
• W2024505897 cites W2166462102 @default.
• W2024505897 doi "https://doi.org/10.1161/01.hyp.20.5.690" @default.
• W2024505897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1385327" @default.
• W2024505897 hasPublicationYear "1992" @default.
• W2024505897 type Work @default.
• W2024505897 sameAs 2024505897 @default.
• W2024505897 citedByCount "49" @default.
• W2024505897 countsByYear W20245058972012 @default.
• W2024505897 countsByYear W20245058972013 @default.
• W2024505897 countsByYear W20245058972014 @default.
• W2024505897 countsByYear W20245058972015 @default.
• W2024505897 crossrefType "journal-article" @default.
• W2024505897 hasAuthorship W2024505897A5004454600 @default.
• W2024505897 hasAuthorship W2024505897A5012918619 @default.
• W2024505897 hasAuthorship W2024505897A5086029201 @default.
• W2024505897 hasBestOaLocation W20245058971 @default.
• W2024505897 hasConcept C126322002 @default.
• W2024505897 hasConcept C134018914 @default.
• W2024505897 hasConcept C2775846464 @default.
• W2024505897 hasConcept C2775915353 @default.
• W2024505897 hasConcept C2778069365 @default.
• W2024505897 hasConcept C2778198053 @default.
• W2024505897 hasConcept C3156946 @default.
• W2024505897 hasConcept C71924100 @default.
• W2024505897 hasConcept C8741621 @default.
• W2024505897 hasConceptScore W2024505897C126322002 @default.
• W2024505897 hasConceptScore W2024505897C134018914 @default.
• W2024505897 hasConceptScore W2024505897C2775846464 @default.
• W2024505897 hasConceptScore W2024505897C2775915353 @default.
• W2024505897 hasConceptScore W2024505897C2778069365 @default.
• W2024505897 hasConceptScore W2024505897C2778198053 @default.
• W2024505897 hasConceptScore W2024505897C3156946 @default.
• W2024505897 hasConceptScore W2024505897C71924100 @default.
• W2024505897 hasConceptScore W2024505897C8741621 @default.
• W2024505897 hasIssue "5" @default.
• W2024505897 hasLocation W20245058971 @default.
• W2024505897 hasLocation W20245058972 @default.
• W2024505897 hasOpenAccess W2024505897 @default.
• W2024505897 hasPrimaryLocation W20245058971 @default.
• W2024505897 hasRelatedWork W1518283686 @default.
• W2024505897 hasRelatedWork W1874790915 @default.
• W2024505897 hasRelatedWork W1972033663 @default.
• W2024505897 hasRelatedWork W2001288055 @default.
• W2024505897 hasRelatedWork W2014120185 @default.
• W2024505897 hasRelatedWork W2070821720 @default.
• W2024505897 hasRelatedWork W2096390902 @default.
• W2024505897 hasRelatedWork W2110614029 @default.
• W2024505897 hasRelatedWork W2147480685 @default.
• W2024505897 hasRelatedWork W2462397896 @default.
• W2024505897 hasVolume "20" @default.
• W2024505897 isParatext "false" @default.
• W2024505897 isRetracted "false" @default.
• W2024505897 magId "2024505897" @default.
• W2024505897 workType "article" @default.