Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024506562> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2024506562 endingPage "104" @default.
- W2024506562 startingPage "98" @default.
- W2024506562 abstract "In tumor radiosurgery, a high dose of radiation is delivered in a single session. The question then naturally arises of selecting an irradiation strategy of high biological efficiency. In this study, the authors propose a mathematical framework to investigate the biological effects of heterogeneity and rate of dose delivery in radiosurgery. The authors simulate a target composed by proliferating and hypoxic tumor cells as well as by normal tissue. Treatment outcome is evaluated by a functional of the dose distribution that counts the LQ-surviving fractions of each cell type. Prescriptions on intensity, homogeneity, and duration of radiation delivery are incorporated as constraints. Biological optimization is performed by means of calculus of variation techniques. For a fixed dose, increasing heterogeneity considerably improved the biological performance. The dose peaks progressively concentrated in the hypoxic and proliferating areas, while damage to normal tissue was reduced. The duration of delivery, optimized in the range of 1-30 min and for various tumor/normal characteristic DNA repair time ratios, coincided with the maximum allowed value. It resulted in a poor therapeutic gain, which was positively correlated with the tumor/normal characteristic DNA repair time ratio. The mathematical framework described in this work allows one to design the dose distribution and dose rate of biologically based plans for tumor radiosurgery. It may be thus integrated into the available simulation softwares to assist in treatment planning." @default.
- W2024506562 created "2016-06-24" @default.
- W2024506562 creator A5030752234 @default.
- W2024506562 creator A5063334043 @default.
- W2024506562 creator A5068866514 @default.
- W2024506562 date "2008-12-09" @default.
- W2024506562 modified "2023-10-14" @default.
- W2024506562 title "Biological optimization of tumor radiosurgery" @default.
- W2024506562 cites W1978240508 @default.
- W2024506562 cites W1986094809 @default.
- W2024506562 cites W1989120270 @default.
- W2024506562 cites W2005951746 @default.
- W2024506562 cites W2009217240 @default.
- W2024506562 cites W2016849571 @default.
- W2024506562 cites W2017781650 @default.
- W2024506562 cites W2023174852 @default.
- W2024506562 cites W2026900109 @default.
- W2024506562 cites W2027501539 @default.
- W2024506562 cites W2050682313 @default.
- W2024506562 cites W2078768340 @default.
- W2024506562 cites W2088368447 @default.
- W2024506562 cites W2123150003 @default.
- W2024506562 cites W4230801261 @default.
- W2024506562 cites W4298361170 @default.
- W2024506562 doi "https://doi.org/10.1118/1.2986141" @default.
- W2024506562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19235378" @default.
- W2024506562 hasPublicationYear "2008" @default.
- W2024506562 type Work @default.
- W2024506562 sameAs 2024506562 @default.
- W2024506562 citedByCount "6" @default.
- W2024506562 countsByYear W20245065622012 @default.
- W2024506562 countsByYear W20245065622014 @default.
- W2024506562 countsByYear W20245065622020 @default.
- W2024506562 crossrefType "journal-article" @default.
- W2024506562 hasAuthorship W2024506562A5030752234 @default.
- W2024506562 hasAuthorship W2024506562A5063334043 @default.
- W2024506562 hasAuthorship W2024506562A5068866514 @default.
- W2024506562 hasConcept C111337013 @default.
- W2024506562 hasConcept C11928243 @default.
- W2024506562 hasConcept C121332964 @default.
- W2024506562 hasConcept C125118446 @default.
- W2024506562 hasConcept C126838900 @default.
- W2024506562 hasConcept C136229726 @default.
- W2024506562 hasConcept C185544564 @default.
- W2024506562 hasConcept C201645570 @default.
- W2024506562 hasConcept C2780387249 @default.
- W2024506562 hasConcept C2989005 @default.
- W2024506562 hasConcept C509974204 @default.
- W2024506562 hasConcept C71924100 @default.
- W2024506562 hasConcept C75088862 @default.
- W2024506562 hasConceptScore W2024506562C111337013 @default.
- W2024506562 hasConceptScore W2024506562C11928243 @default.
- W2024506562 hasConceptScore W2024506562C121332964 @default.
- W2024506562 hasConceptScore W2024506562C125118446 @default.
- W2024506562 hasConceptScore W2024506562C126838900 @default.
- W2024506562 hasConceptScore W2024506562C136229726 @default.
- W2024506562 hasConceptScore W2024506562C185544564 @default.
- W2024506562 hasConceptScore W2024506562C201645570 @default.
- W2024506562 hasConceptScore W2024506562C2780387249 @default.
- W2024506562 hasConceptScore W2024506562C2989005 @default.
- W2024506562 hasConceptScore W2024506562C509974204 @default.
- W2024506562 hasConceptScore W2024506562C71924100 @default.
- W2024506562 hasConceptScore W2024506562C75088862 @default.
- W2024506562 hasIssue "1" @default.
- W2024506562 hasLocation W20245065621 @default.
- W2024506562 hasLocation W20245065622 @default.
- W2024506562 hasOpenAccess W2024506562 @default.
- W2024506562 hasPrimaryLocation W20245065621 @default.
- W2024506562 hasRelatedWork W108213934 @default.
- W2024506562 hasRelatedWork W1163825299 @default.
- W2024506562 hasRelatedWork W1602881370 @default.
- W2024506562 hasRelatedWork W1972672654 @default.
- W2024506562 hasRelatedWork W1983863207 @default.
- W2024506562 hasRelatedWork W2025656351 @default.
- W2024506562 hasRelatedWork W2076776398 @default.
- W2024506562 hasRelatedWork W2100602797 @default.
- W2024506562 hasRelatedWork W2167624373 @default.
- W2024506562 hasRelatedWork W2424176838 @default.
- W2024506562 hasVolume "36" @default.
- W2024506562 isParatext "false" @default.
- W2024506562 isRetracted "false" @default.
- W2024506562 magId "2024506562" @default.
- W2024506562 workType "article" @default.