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- W2024508246 abstract "Primary mediastinal B-cell lymphoma (PMBCL) is a recognised subtype of diffuse large B-cell lymphoma according to the WHO classification that represents approximately 5% of aggressive lymphomas, and 2% of all cases of lymphomas. It presents with unique clinical, morphologic and immunophenotypic characteristics that define the disease. Retrospective studies have found that PMBCL patients have excellent survival rates with a distinct plateau and a trend to better outcome if treated with dose-intensified chemotherapy with MACOPB or VACOPB. In spite of the multiple molecular data known, generated on the pathogenesis of this tumour, treatment is still essentially based on a combination of chemo and immunotherapy. We take this opportunity for reviewing the recent biologic data provided by gene expression profiling of the tumour, for discussing new potential therapeutic targets." @default.
- W2024508246 created "2016-06-24" @default.
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- W2024508246 date "2008-01-01" @default.
- W2024508246 modified "2023-10-01" @default.
- W2024508246 title "Primary mediastinal B-cell lymphoma: Treatment and therapeutic targets" @default.
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- W2024508246 doi "https://doi.org/10.1080/10428190801958994" @default.
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