FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024519775> ?p ?o ?g. }

• W2024519775 endingPage "262" @default.
• W2024519775 startingPage "257" @default.
• W2024519775 abstract "Background Our previous studies showed that topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) is very effective for oral verrucous hyperplasia (OVH) and relatively less effective for oral leukoplakia (OL) lesions. Nevertheless, there has been no report on the association of the expression of apoptosis-related proteins in OVH and OL biopsy tissues prior to PDT with PDT treatment outcomes. Methods This study used immunohistochemistry to evaluate whether the expression of Bak, Mcl-1, caspase-3, caspase-8, caspase-9, p53, p21, or PCNA protein in biopsy specimens of OVH and OL lesions could be used to predict the clinical outcomes of 18 OVH and 40 OL lesions treated with topical ALA-PDT. The marker labeling score (LS) was defined as labeling index (positive cells/total cells) multiplied by staining intensity. The lesions after ALA-PDT treatment were divided into complete response (CR) group and partial or no response (PR/NR) group. Results The mean Bak LS and the mean Bak/Mcl-1 LS ratio were significantly higher in the CR group than in the PR/NR group. However, there was no significant difference in the Mcl-1, caspase-3, caspase-8, caspase-9, p53, p21, or PCNA protein LS between the CR and PR/NR groups. Conclusion We conclude that the Bak LS or Bak/Mcl-1 LS ratio may be a useful biomarker to predict the clinical outcomes of OVH and OL lesions treated with topical ALA-PDT. Pre-PDT epithelial cell levels of Mcl-1, caspase-3, caspase-8, caspase-9, p53, p21, and PCNA may not have a significant influence on the clinical outcome of OVH and OL lesions treated with topical ALA-PDT." @default.
• W2024519775 created "2016-06-24" @default.
• W2024519775 creator A5004139477 @default.
• W2024519775 creator A5054820201 @default.
• W2024519775 creator A5063887894 @default.
• W2024519775 creator A5076458680 @default.
• W2024519775 date "2012-09-14" @default.
• W2024519775 modified "2023-10-15" @default.
• W2024519775 title "Expression of Bak and Bak/Mcl-1 ratio can predict photodynamic therapy outcome for oral verrucous hyperplasia and leukoplakia" @default.
• W2024519775 cites W1550995332 @default.
• W2024519775 cites W1745634660 @default.
• W2024519775 cites W1824084722 @default.
• W2024519775 cites W1913661233 @default.
• W2024519775 cites W1970547525 @default.
• W2024519775 cites W1976316075 @default.
• W2024519775 cites W1976779224 @default.
• W2024519775 cites W1984547206 @default.
• W2024519775 cites W1999142777 @default.
• W2024519775 cites W2003282728 @default.
• W2024519775 cites W2006626786 @default.
• W2024519775 cites W2007127627 @default.
• W2024519775 cites W2015066175 @default.
• W2024519775 cites W2017736723 @default.
• W2024519775 cites W2019412962 @default.
• W2024519775 cites W2039681820 @default.
• W2024519775 cites W2042357862 @default.
• W2024519775 cites W2048668476 @default.
• W2024519775 cites W2053225461 @default.
• W2024519775 cites W2068213332 @default.
• W2024519775 cites W2078188245 @default.
• W2024519775 cites W2088805436 @default.
• W2024519775 cites W2092473092 @default.
• W2024519775 cites W2099113454 @default.
• W2024519775 cites W2109645616 @default.
• W2024519775 cites W2110224945 @default.
• W2024519775 cites W2135080095 @default.
• W2024519775 cites W2141210575 @default.
• W2024519775 cites W2150208731 @default.
• W2024519775 cites W2166467949 @default.
• W2024519775 cites W2326815857 @default.
• W2024519775 cites W4211024586 @default.
• W2024519775 cites W4253799986 @default.
• W2024519775 cites W4254786257 @default.
• W2024519775 doi "https://doi.org/10.1111/jop.12007" @default.
• W2024519775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22974427" @default.
• W2024519775 hasPublicationYear "2012" @default.
• W2024519775 type Work @default.
• W2024519775 sameAs 2024519775 @default.
• W2024519775 citedByCount "10" @default.
• W2024519775 countsByYear W20245197752013 @default.
• W2024519775 countsByYear W20245197752014 @default.
• W2024519775 countsByYear W20245197752015 @default.
• W2024519775 countsByYear W20245197752018 @default.
• W2024519775 countsByYear W20245197752019 @default.
• W2024519775 countsByYear W20245197752022 @default.
• W2024519775 countsByYear W20245197752023 @default.
• W2024519775 crossrefType "journal-article" @default.
• W2024519775 hasAuthorship W2024519775A5004139477 @default.
• W2024519775 hasAuthorship W2024519775A5054820201 @default.
• W2024519775 hasAuthorship W2024519775A5063887894 @default.
• W2024519775 hasAuthorship W2024519775A5076458680 @default.
• W2024519775 hasBestOaLocation W20245197752 @default.
• W2024519775 hasConcept C12519072 @default.
• W2024519775 hasConcept C142724271 @default.
• W2024519775 hasConcept C143998085 @default.
• W2024519775 hasConcept C178790620 @default.
• W2024519775 hasConcept C185592680 @default.
• W2024519775 hasConcept C190283241 @default.
• W2024519775 hasConcept C204232928 @default.
• W2024519775 hasConcept C2775934546 @default.
• W2024519775 hasConcept C2781323092 @default.
• W2024519775 hasConcept C31573885 @default.
• W2024519775 hasConcept C34688535 @default.
• W2024519775 hasConcept C502942594 @default.
• W2024519775 hasConcept C55493867 @default.
• W2024519775 hasConcept C71924100 @default.
• W2024519775 hasConcept C86803240 @default.
• W2024519775 hasConceptScore W2024519775C12519072 @default.
• W2024519775 hasConceptScore W2024519775C142724271 @default.
• W2024519775 hasConceptScore W2024519775C143998085 @default.
• W2024519775 hasConceptScore W2024519775C178790620 @default.
• W2024519775 hasConceptScore W2024519775C185592680 @default.
• W2024519775 hasConceptScore W2024519775C190283241 @default.
• W2024519775 hasConceptScore W2024519775C204232928 @default.
• W2024519775 hasConceptScore W2024519775C2775934546 @default.
• W2024519775 hasConceptScore W2024519775C2781323092 @default.
• W2024519775 hasConceptScore W2024519775C31573885 @default.
• W2024519775 hasConceptScore W2024519775C34688535 @default.
• W2024519775 hasConceptScore W2024519775C502942594 @default.
• W2024519775 hasConceptScore W2024519775C55493867 @default.
• W2024519775 hasConceptScore W2024519775C71924100 @default.
• W2024519775 hasConceptScore W2024519775C86803240 @default.
• W2024519775 hasIssue "3" @default.
• W2024519775 hasLocation W20245197751 @default.
• W2024519775 hasLocation W20245197752 @default.
• W2024519775 hasLocation W20245197753 @default.
• W2024519775 hasOpenAccess W2024519775 @default.
• W2024519775 hasPrimaryLocation W20245197751 @default.

• next