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- W2024522456 abstract "THE present investigation provide evidences from a non-human primate model that naturally occurring menopause predicts a prominent signature of age-related cognitive decline. Young and aged rhesus monkeys were tested on a delayed response (DR) task known to be sensitive to aging, and reproductive status was evaluated according to menstrual cyclicity and urinary hormone profiles. Peri-/postmenopausal monkeys exhibited significant DR impairments relative to either agematched premenopausal females, or young control subjects. In addition, markers of endocrine decline in the aged animals were selectively correlated with behavioral performance measures that distinguished premenopausal and peri-/postmenopausal monkeys. These results document that menopause is coupled to cognitive decline in the monkey, and they establish a valuable primate model for defining the effects of endocrine aging on brain and behavioral function." @default.
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- W2024522456 date "1997-05-01" @default.
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- W2024522456 title "Reproductive senescence predicts cognitive decline in aged female monkeys" @default.
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- W2024522456 doi "https://doi.org/10.1097/00001756-199705260-00048" @default.
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