Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024523907> ?p ?o ?g. }
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- W2024523907 startingPage "234" @default.
- W2024523907 abstract "The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high molecular weight kininogen (HK). The conversion of plasma prekallikrein to kallikrein by the activated FXII and in response to numerous different stimuli leads to the generation of bradykinin (BK) and activated HK (HKa, an antiangiogenic peptide). BK is a proinflammatory peptide, a pain mediator and potent vasodilator, leading to robust accumulation of fluid in the interstitium. Systemic production of BK, HKa with the interplay between BK bound-BK receptors and the soluble form of HKa are key to angiogenesis and hemodynamics. KKS has been implicated in the pathogenesis of inflammation, hypertension, endotoxemia, and coagulopathy. In all these cases increased BK levels is the hallmark. In some cases, the persistent production of BK due to the deficiency of the blood protein C1-inhibitor, which controls FXII, is detrimental to the survival of the patients with hereditary angioedema (HAE). In others, the inability of angiotensin converting enzyme (ACE) to degrade BK leads to elevated BK levels and edema in patients on ACE inhibitors. Thus, the mechanisms that interfere with BK liberation or degradation would lead to blood pressure dysfunction. In contrast, anti-kallikrein treatment could have adverse effects in hemodynamic changes induced by vasoconstrictor agents. Genetic models of kallikrein deficiency are needed to evaluate the quantitative role of kallikrein and to validate whether strategies designed to activate or inhibit kallikrein may be important for regulating whole-body BK sensitivity." @default.
- W2024523907 created "2016-06-24" @default.
- W2024523907 creator A5000699962 @default.
- W2024523907 creator A5081038993 @default.
- W2024523907 date "2009-07-01" @default.
- W2024523907 modified "2023-10-01" @default.
- W2024523907 title "Human Plasma Kallikrein-Kinin System: Physiological and Biochemical Parameters" @default.
- W2024523907 cites W100325461 @default.
- W2024523907 cites W11153108 @default.
- W2024523907 cites W135886098 @default.
- W2024523907 cites W135886672 @default.
- W2024523907 cites W143880323 @default.
- W2024523907 cites W146908776 @default.
- W2024523907 cites W1493910160 @default.
- W2024523907 cites W1500508767 @default.
- W2024523907 cites W1519621899 @default.
- W2024523907 cites W1521836177 @default.
- W2024523907 cites W1524686766 @default.
- W2024523907 cites W1537023075 @default.
- W2024523907 cites W153985015 @default.
- W2024523907 cites W1564480246 @default.
- W2024523907 cites W156655195 @default.
- W2024523907 cites W158495152 @default.
- W2024523907 cites W1590399316 @default.
- W2024523907 cites W1604352043 @default.
- W2024523907 cites W1607135580 @default.
- W2024523907 cites W1607236619 @default.
- W2024523907 cites W1627592913 @default.
- W2024523907 cites W166380481 @default.
- W2024523907 cites W178558460 @default.
- W2024523907 cites W1861020171 @default.
- W2024523907 cites W1889139395 @default.
- W2024523907 cites W1919703464 @default.
- W2024523907 cites W1963952199 @default.
- W2024523907 cites W1965058977 @default.
- W2024523907 cites W1966026137 @default.
- W2024523907 cites W1966682053 @default.
- W2024523907 cites W1968287223 @default.
- W2024523907 cites W1969467517 @default.
- W2024523907 cites W1970030235 @default.
- W2024523907 cites W1971277556 @default.
- W2024523907 cites W1971365741 @default.
- W2024523907 cites W1973569420 @default.
- W2024523907 cites W1975350992 @default.
- W2024523907 cites W1976772170 @default.
- W2024523907 cites W1976941495 @default.
- W2024523907 cites W1978220538 @default.
- W2024523907 cites W1979374380 @default.
- W2024523907 cites W1980065167 @default.
- W2024523907 cites W1980371147 @default.
- W2024523907 cites W1983438490 @default.
- W2024523907 cites W1983475214 @default.
- W2024523907 cites W1985171529 @default.
- W2024523907 cites W1985484598 @default.
- W2024523907 cites W1985619310 @default.
- W2024523907 cites W1992695367 @default.
- W2024523907 cites W1994533959 @default.
- W2024523907 cites W1994610964 @default.
- W2024523907 cites W1995304960 @default.
- W2024523907 cites W1996000902 @default.
- W2024523907 cites W1998268365 @default.
- W2024523907 cites W1998336764 @default.
- W2024523907 cites W1999137479 @default.
- W2024523907 cites W2001567952 @default.
- W2024523907 cites W2002341869 @default.
- W2024523907 cites W2004090021 @default.
- W2024523907 cites W2004714575 @default.
- W2024523907 cites W2004985892 @default.
- W2024523907 cites W2007502554 @default.
- W2024523907 cites W2014802742 @default.
- W2024523907 cites W2014991577 @default.
- W2024523907 cites W2015437707 @default.
- W2024523907 cites W2015479410 @default.
- W2024523907 cites W2019033741 @default.
- W2024523907 cites W2019212364 @default.
- W2024523907 cites W2020400042 @default.
- W2024523907 cites W2026562859 @default.
- W2024523907 cites W2027346283 @default.
- W2024523907 cites W2028964742 @default.
- W2024523907 cites W2029559190 @default.
- W2024523907 cites W2031531898 @default.
- W2024523907 cites W2033089482 @default.
- W2024523907 cites W2033740699 @default.
- W2024523907 cites W2036688878 @default.
- W2024523907 cites W2038564379 @default.
- W2024523907 cites W2041349540 @default.
- W2024523907 cites W2042379517 @default.
- W2024523907 cites W2046200797 @default.
- W2024523907 cites W2046597139 @default.
- W2024523907 cites W2047458615 @default.
- W2024523907 cites W2049971614 @default.
- W2024523907 cites W2050220138 @default.
- W2024523907 cites W2050287667 @default.
- W2024523907 cites W2050632379 @default.
- W2024523907 cites W2050959950 @default.
- W2024523907 cites W2050968477 @default.
- W2024523907 cites W2051198459 @default.
- W2024523907 cites W2051244685 @default.