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• W2024525066 abstract "The potential usefulness of antimicrobial peptides (AMPs) as antimycobacterial compounds has not been extensively explored. Although a myriad of studies on AMPs from different sources have been done, some of its mechanisms of action are still unknown. Maganins are of particular interest since they do not lyse non-dividing mammalian cells. In this work, AMPs with well-recognized activity against bacteria were synthesized, characterized, purified and their antimycobacterial activity and influence on ATPase activity in mycobacterial plasma membrane vesicles were assessed. Using bioinformatics tools, a magainin-I analog peptide (MIAP) with improved antimicrobial activity was designed. The influence of MIAP on proton (H+) pumping mediated by F1F0-ATPase in plasma membrane vesicles obtained from Mycobacterium tuberculosis was evaluated. We observed that the antimycobacterial activity of AMPs was low and variable. However, the activity of the designed peptide MIAP against M. tuberculosis was 2-fold higher in comparison to magainin-I. The basal ATPase activity of mycobacterial plasma membrane vesicles decreased approximately 24–30% in the presence of AMPs. On the other hand, the MIAP peptide completely abolished the F1F0-ATPase activity involved in H+ pumping across M. tuberculosis plasma membranes vesicles at levels similar to the specific inhibitor N,N′ dicyclohexylcarbodiimide. These finding suggest that AMPs can inhibit the H+ pumping F1F0-ATPase of mycobacterial plasma membrane that potentially interferes the internal pH and viability of mycobacteria." @default.
• W2024525066 created "2016-06-24" @default.
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• W2024525066 date "2012-07-01" @default.
• W2024525066 modified "2023-10-14" @default.
• W2024525066 title "Effect of antimicrobial peptides on ATPase activity and proton pumping in plasma membrane vesicles obtained from mycobacteria" @default.
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• W2024525066 doi "https://doi.org/10.1016/j.peptides.2012.04.018" @default.
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