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- W2024530076 abstract "Sezary syndrome is a leukemic variant of cutaneous T-cell lymphoma characterized by the appearance of numerous CD4+ cells with cerebriform nuclei in the peripheral blood. Recent observations have suggested that Sezary cells lack CD7 molecules on their surface and are analogous to murine Th2 cells. It remains unclear, however, whether these two properties are actually common features of Sezary cells. We describe a case of Sezary syndroem in which more than 98% of the peripheral blood mononuclear cells expressed CD7 as well as a homogeneous T-cell receptor Vα2Vβ17, indicative of the expression of CD7 as well as a homogeneous Although the circulating Sezary cells continuously bore CD7 molecule on their surface throughout the patient's clinical course, the intensity of CD7 expression was variable in skininfiltrating and in vitro cultured cells. Peripheral blood mononuclear cells from the patient proliferated well to a Vβ17-relevant superantigen (staphylococcal enterotoxin B) but not to irrelevant superantigens; produced interleukin-2, interferon gamma, and tumor necrosis factor-α, but not interleukin-4; and transcribed messenger RNA for interleukin-2 and interferon gamma but not interleukin-4 or interleukin-10. This represents an unusual case of a CD7+ Sezary syndrome with a cytokine profile characteristic of Th1 cells." @default.
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- W2024530076 date "1994-08-01" @default.
- W2024530076 modified "2023-09-27" @default.
- W2024530076 title "CD7-positive Sezary syndrome with a TH1 cytokine profile" @default.
- W2024530076 doi "https://doi.org/10.1016/0923-1811(94)90489-8" @default.
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