Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024532057> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2024532057 abstract "Ribosomal protein S13 of the nematode Brugia pahangi is recognized by B and T cells from parasite-infected animals. To identify helper T cell sites on the protein, 15 overlapping synthetic peptides spanning the entire molecule (Bp17.4) were tested for their ability to stimulate lymph node and spleen cells of peptide-immunized and recombinant antigen-immunized jirds. Lymph node cells from animals immunized with peptides 6, 8, 9, 13, and 14, corresponding to Bp17.4 amino acids (AA) 50-70, 70-90, 80-100, 120-140, and 130-150, respectively, showed strong and specific responses to the homologous peptide, while only those lymph node cells from jirds immunized with peptides 8, 9, 13, and 14 proliferated in response to Bp17.4. These results suggest the existence of at least two T cell epitopes. Lymph node cells from infected jirds also responded to these peptides and to Bp17.4 (80,000 cpm). In contrast to the lymph node cells, spleen cells from microfilaria-positive animals failed to mount significant responses to any of the peptides or to Bp17.4. Splenic T cell responsiveness was restored upon removal of nylon wool adherent cells, suggesting active regulation of Bp17.4 reactivity. In liquid-phase competitive inhibition immunoassays, peptides 1 (AA 1-30) and 6 (50-70) blocked antibody binding and, therefore, these regions contain conformational antibody-binding sites. This model system should prove useful for analyzing regulation of epitope-specific responses in experimental filariasis." @default.
- W2024532057 created "2016-06-24" @default.
- W2024532057 creator A5022464674 @default.
- W2024532057 creator A5071496730 @default.
- W2024532057 date "1992-11-01" @default.
- W2024532057 modified "2023-10-16" @default.
- W2024532057 title "Immunologic characterization of jird lymphocyte responsiveness to Brugia pahangi ribosomal protein S13" @default.
- W2024532057 cites W1482502955 @default.
- W2024532057 cites W1484382785 @default.
- W2024532057 cites W1492381049 @default.
- W2024532057 cites W1598835405 @default.
- W2024532057 cites W162098164 @default.
- W2024532057 cites W1875076850 @default.
- W2024532057 cites W1969704830 @default.
- W2024532057 cites W1990635550 @default.
- W2024532057 cites W2020254208 @default.
- W2024532057 cites W2046281538 @default.
- W2024532057 cites W2064005745 @default.
- W2024532057 cites W2079628834 @default.
- W2024532057 cites W2084093106 @default.
- W2024532057 cites W2094954825 @default.
- W2024532057 cites W2109221117 @default.
- W2024532057 cites W2113500147 @default.
- W2024532057 cites W2162788913 @default.
- W2024532057 cites W2293041249 @default.
- W2024532057 cites W2397482293 @default.
- W2024532057 cites W2404444349 @default.
- W2024532057 cites W2407464523 @default.
- W2024532057 cites W2419672378 @default.
- W2024532057 cites W575092863 @default.
- W2024532057 doi "https://doi.org/10.1016/0014-4894(92)90214-u" @default.
- W2024532057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1385208" @default.
- W2024532057 hasPublicationYear "1992" @default.
- W2024532057 type Work @default.
- W2024532057 sameAs 2024532057 @default.
- W2024532057 citedByCount "0" @default.
- W2024532057 crossrefType "journal-article" @default.
- W2024532057 hasAuthorship W2024532057A5022464674 @default.
- W2024532057 hasAuthorship W2024532057A5071496730 @default.
- W2024532057 hasConcept C147483822 @default.
- W2024532057 hasConcept C153911025 @default.
- W2024532057 hasConcept C159654299 @default.
- W2024532057 hasConcept C165901193 @default.
- W2024532057 hasConcept C195616568 @default.
- W2024532057 hasConcept C203014093 @default.
- W2024532057 hasConcept C2775848585 @default.
- W2024532057 hasConcept C2776573122 @default.
- W2024532057 hasConcept C2777629521 @default.
- W2024532057 hasConcept C2780849966 @default.
- W2024532057 hasConcept C2780931953 @default.
- W2024532057 hasConcept C86803240 @default.
- W2024532057 hasConceptScore W2024532057C147483822 @default.
- W2024532057 hasConceptScore W2024532057C153911025 @default.
- W2024532057 hasConceptScore W2024532057C159654299 @default.
- W2024532057 hasConceptScore W2024532057C165901193 @default.
- W2024532057 hasConceptScore W2024532057C195616568 @default.
- W2024532057 hasConceptScore W2024532057C203014093 @default.
- W2024532057 hasConceptScore W2024532057C2775848585 @default.
- W2024532057 hasConceptScore W2024532057C2776573122 @default.
- W2024532057 hasConceptScore W2024532057C2777629521 @default.
- W2024532057 hasConceptScore W2024532057C2780849966 @default.
- W2024532057 hasConceptScore W2024532057C2780931953 @default.
- W2024532057 hasConceptScore W2024532057C86803240 @default.
- W2024532057 hasLocation W20245320571 @default.
- W2024532057 hasLocation W20245320572 @default.
- W2024532057 hasOpenAccess W2024532057 @default.
- W2024532057 hasPrimaryLocation W20245320571 @default.
- W2024532057 hasRelatedWork W1965748505 @default.
- W2024532057 hasRelatedWork W1980448162 @default.
- W2024532057 hasRelatedWork W2072388873 @default.
- W2024532057 hasRelatedWork W2090842992 @default.
- W2024532057 hasRelatedWork W2118155575 @default.
- W2024532057 hasRelatedWork W2324312617 @default.
- W2024532057 hasRelatedWork W2394628144 @default.
- W2024532057 hasRelatedWork W2413858146 @default.
- W2024532057 hasRelatedWork W2474689416 @default.
- W2024532057 hasRelatedWork W42891068 @default.
- W2024532057 isParatext "false" @default.
- W2024532057 isRetracted "false" @default.
- W2024532057 magId "2024532057" @default.
- W2024532057 workType "article" @default.