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- W2024534479 abstract "Bacteria monitor their local population densities using small molecules (or autoinducers) in a process known as quorum sensing. Here, we report a new and efficient synthetic route to naturally occurring bacterial autoinducers [N-acyl l-homoserine lactones (AHLs)] that is readily amenable to the synthesis of analogues. This route has been applied in the first synthesis of a library of non-native AHLs. Evaluation of these compounds in bacterial reporter gene and biofilm assays has revealed a potent set of quorum sensing antagonists. These ligands will serve as valuable new tools to explore the role of quorum sensing in bacterial pathogenesis." @default.
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- W2024534479 date "2005-08-26" @default.
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- W2024534479 title "Small Molecule Inhibitors of Bacterial Quorum Sensing and Biofilm Formation" @default.
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- W2024534479 doi "https://doi.org/10.1021/ja0530321" @default.
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