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• W2024535359 abstract "Antipsychotic-induced weight gain has important effects on treatment compliance and long-term health. Several reports have indicated that a -2548A/G single-nucleotide polymorphism (SNP) of the leptin gene is associated with antipsychotic-induced weight gain. We hypothesized that there is a similar relationship between the -2548A/G SNP and olanzapine-induced weight gain. A total of 74 Korean schizophrenic patients were examined. Their weight was measured before starting olanzapine and after long-term treatment lasting for at least 3 months. The weight gain was significantly higher for patients with the AG genotype than for those with the AA genotype (p=0.029). Analysis of covariance also showed the difference of weight gain was still significant when adjusted for sex and treatment duration (p=0.046). This finding supports the presence of a relationship between the -2548A/G SNP of the leptin gene and weight gain in Korean schizophrenic patients receiving olanzapine treatment." @default.
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• W2024535359 date "2008-01-01" @default.
• W2024535359 modified "2023-10-16" @default.
• W2024535359 title "Possible association between the −2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain" @default.
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• W2024535359 doi "https://doi.org/10.1016/j.pnpbp.2007.08.002" @default.
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