FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024536415> ?p ?o ?g. }

• W2024536415 endingPage "401" @default.
• W2024536415 startingPage "395" @default.
• W2024536415 abstract "The recent success in treating chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKI), such as imatinib mesylate (IM), has created a demand for reproducible methods to accurately assess inhibition of BCR-ABL activity within CML cells, including rare stem and progenitor cells, either in vitro or in vivo. The purpose of this study was to develop an enzyme-linked immunosorbent (ELISA) method to measure total tyrosine phosphorylation (P-Tyr) in small samples of cells that express BCR-ABL and to compare to more established methods.The assay was first validated in BCR-ABL wild-type and mutant vs BCR-ABL-negative cell lines. P-Tyr levels were then measured by ELISA in primary CD34(+) CML cells treated with IM.In vitro exposure to TKI resulted in decreases in the level of P-Tyr, in both BCR-ABL-positive cell lines and primary CD34(+) CML samples, which were comparable to the reduction in P-Tyr by flow cytometry and phosphorylation of CrkL by either Western blot or flow cytometry.We have developed an accurate ELISA method to measure BCR-ABL activity within Ph(+) cells, which is comparable to other in vitro BCR-ABL assessment techniques in terms of sensitivity and could be adapted for high throughput." @default.
• W2024536415 created "2016-06-24" @default.
• W2024536415 creator A5020420655 @default.
• W2024536415 creator A5047732858 @default.
• W2024536415 creator A5073585582 @default.
• W2024536415 creator A5073897739 @default.
• W2024536415 creator A5087500042 @default.
• W2024536415 date "2009-03-01" @default.
• W2024536415 modified "2023-10-16" @default.
• W2024536415 title "Optimization of methods for the detection of BCR-ABL activity in Philadelphia-positive cells" @default.
• W2024536415 cites W1484834653 @default.
• W2024536415 cites W1529003705 @default.
• W2024536415 cites W1964306758 @default.
• W2024536415 cites W1970186200 @default.
• W2024536415 cites W1977728980 @default.
• W2024536415 cites W1987239635 @default.
• W2024536415 cites W1988446426 @default.
• W2024536415 cites W1988682297 @default.
• W2024536415 cites W1995066709 @default.
• W2024536415 cites W1998593414 @default.
• W2024536415 cites W2003973314 @default.
• W2024536415 cites W2014316424 @default.
• W2024536415 cites W2016086822 @default.
• W2024536415 cites W2017001374 @default.
• W2024536415 cites W2020092689 @default.
• W2024536415 cites W2028959752 @default.
• W2024536415 cites W2037220012 @default.
• W2024536415 cites W2041004587 @default.
• W2024536415 cites W2057375535 @default.
• W2024536415 cites W2083353096 @default.
• W2024536415 cites W2107268345 @default.
• W2024536415 cites W2123772306 @default.
• W2024536415 cites W2124196948 @default.
• W2024536415 cites W2149468947 @default.
• W2024536415 cites W2327418980 @default.
• W2024536415 doi "https://doi.org/10.1016/j.exphem.2008.11.005" @default.
• W2024536415 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19135772" @default.
• W2024536415 hasPublicationYear "2009" @default.
• W2024536415 type Work @default.
• W2024536415 sameAs 2024536415 @default.
• W2024536415 citedByCount "9" @default.
• W2024536415 countsByYear W20245364152014 @default.
• W2024536415 countsByYear W20245364152018 @default.
• W2024536415 countsByYear W20245364152019 @default.
• W2024536415 countsByYear W20245364152020 @default.
• W2024536415 crossrefType "journal-article" @default.
• W2024536415 hasAuthorship W2024536415A5020420655 @default.
• W2024536415 hasAuthorship W2024536415A5047732858 @default.
• W2024536415 hasAuthorship W2024536415A5073585582 @default.
• W2024536415 hasAuthorship W2024536415A5073897739 @default.
• W2024536415 hasAuthorship W2024536415A5087500042 @default.
• W2024536415 hasBestOaLocation W20245364151 @default.
• W2024536415 hasConcept C10205521 @default.
• W2024536415 hasConcept C125418893 @default.
• W2024536415 hasConcept C153911025 @default.
• W2024536415 hasConcept C170493617 @default.
• W2024536415 hasConcept C185592680 @default.
• W2024536415 hasConcept C201750760 @default.
• W2024536415 hasConcept C2777583451 @default.
• W2024536415 hasConcept C2778729363 @default.
• W2024536415 hasConcept C28328180 @default.
• W2024536415 hasConcept C3019892230 @default.
• W2024536415 hasConcept C42362537 @default.
• W2024536415 hasConcept C43907098 @default.
• W2024536415 hasConcept C502942594 @default.
• W2024536415 hasConcept C54355233 @default.
• W2024536415 hasConcept C553184892 @default.
• W2024536415 hasConcept C55493867 @default.
• W2024536415 hasConcept C62478195 @default.
• W2024536415 hasConcept C81885089 @default.
• W2024536415 hasConcept C86803240 @default.
• W2024536415 hasConcept C95444343 @default.
• W2024536415 hasConceptScore W2024536415C10205521 @default.
• W2024536415 hasConceptScore W2024536415C125418893 @default.
• W2024536415 hasConceptScore W2024536415C153911025 @default.
• W2024536415 hasConceptScore W2024536415C170493617 @default.
• W2024536415 hasConceptScore W2024536415C185592680 @default.
• W2024536415 hasConceptScore W2024536415C201750760 @default.
• W2024536415 hasConceptScore W2024536415C2777583451 @default.
• W2024536415 hasConceptScore W2024536415C2778729363 @default.
• W2024536415 hasConceptScore W2024536415C28328180 @default.
• W2024536415 hasConceptScore W2024536415C3019892230 @default.
• W2024536415 hasConceptScore W2024536415C42362537 @default.
• W2024536415 hasConceptScore W2024536415C43907098 @default.
• W2024536415 hasConceptScore W2024536415C502942594 @default.
• W2024536415 hasConceptScore W2024536415C54355233 @default.
• W2024536415 hasConceptScore W2024536415C553184892 @default.
• W2024536415 hasConceptScore W2024536415C55493867 @default.
• W2024536415 hasConceptScore W2024536415C62478195 @default.
• W2024536415 hasConceptScore W2024536415C81885089 @default.
• W2024536415 hasConceptScore W2024536415C86803240 @default.
• W2024536415 hasConceptScore W2024536415C95444343 @default.
• W2024536415 hasIssue "3" @default.
• W2024536415 hasLocation W20245364151 @default.
• W2024536415 hasLocation W20245364152 @default.
• W2024536415 hasOpenAccess W2024536415 @default.
• W2024536415 hasPrimaryLocation W20245364151 @default.
• W2024536415 hasRelatedWork W14061706 @default.

• next