Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024540209> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2024540209 endingPage "S145" @default.
- W2024540209 startingPage "S144" @default.
- W2024540209 abstract "Congenital dislocation of the hip (CDH), which is one of the most common congenital skeletal disorders, corresponds to an abnormal seating of the femoral head in the acetabulum. It is commonly admitted that CDH presents a genetic component. However, little is known about the genetic factors involved. This study aimed to determine the role of two potential candidate genes on chromosome 17 in CDH: HOXB9 (involved in limb embryonic development) and COL1A1 (involved in joint laxity).We set up a case-control association study (239 cases and 239 controls) in western Brittany (France) where CDH is particularly frequent. The set of informative single nucleotide polymorphisms (SNPs) in each gene was selected using Tagger and genotyped using the SNaPshot® method (n = 2 and n = 10, respectively). The association was tested both through single-locus and haplotype-based analyses, using SAS and Haploview softwares. In addition, we carried out the transmission disequilibrium test (TDT) with the same polymorphisms from a sample of 81 trios (i.e., 81 patients included in the case-control study and their both parents).The case-control study revealed no significant association between CDH and the tagSNPs selected in both HOXB9 and COL1A1. Moreover, the TDT did not reveal distortion in allelic and haplotype transmission of the studied markers.Our study did not support an association between HOXB9 and COL1A1 and CDH in our population. These negative findings were obtained by population- and family-based designs. Analysis of the genetic component of CDH should focus on other candidate genes." @default.
- W2024540209 created "2016-06-24" @default.
- W2024540209 creator A5004610189 @default.
- W2024540209 creator A5067600290 @default.
- W2024540209 creator A5080614846 @default.
- W2024540209 date "2011-04-01" @default.
- W2024540209 modified "2023-09-26" @default.
- W2024540209 title "P.3.005 Dilept - a novel type of antipsychotic based on neurotensin" @default.
- W2024540209 doi "https://doi.org/10.1016/s0924-977x(11)70173-0" @default.
- W2024540209 hasPublicationYear "2011" @default.
- W2024540209 type Work @default.
- W2024540209 sameAs 2024540209 @default.
- W2024540209 citedByCount "1" @default.
- W2024540209 crossrefType "journal-article" @default.
- W2024540209 hasAuthorship W2024540209A5004610189 @default.
- W2024540209 hasAuthorship W2024540209A5067600290 @default.
- W2024540209 hasAuthorship W2024540209A5080614846 @default.
- W2024540209 hasConcept C104317684 @default.
- W2024540209 hasConcept C135763542 @default.
- W2024540209 hasConcept C153209595 @default.
- W2024540209 hasConcept C180754005 @default.
- W2024540209 hasConcept C186413461 @default.
- W2024540209 hasConcept C197754878 @default.
- W2024540209 hasConcept C2776885448 @default.
- W2024540209 hasConcept C2908647359 @default.
- W2024540209 hasConcept C35605836 @default.
- W2024540209 hasConcept C54355233 @default.
- W2024540209 hasConcept C69991583 @default.
- W2024540209 hasConcept C71924100 @default.
- W2024540209 hasConcept C84597430 @default.
- W2024540209 hasConcept C86803240 @default.
- W2024540209 hasConcept C99454951 @default.
- W2024540209 hasConceptScore W2024540209C104317684 @default.
- W2024540209 hasConceptScore W2024540209C135763542 @default.
- W2024540209 hasConceptScore W2024540209C153209595 @default.
- W2024540209 hasConceptScore W2024540209C180754005 @default.
- W2024540209 hasConceptScore W2024540209C186413461 @default.
- W2024540209 hasConceptScore W2024540209C197754878 @default.
- W2024540209 hasConceptScore W2024540209C2776885448 @default.
- W2024540209 hasConceptScore W2024540209C2908647359 @default.
- W2024540209 hasConceptScore W2024540209C35605836 @default.
- W2024540209 hasConceptScore W2024540209C54355233 @default.
- W2024540209 hasConceptScore W2024540209C69991583 @default.
- W2024540209 hasConceptScore W2024540209C71924100 @default.
- W2024540209 hasConceptScore W2024540209C84597430 @default.
- W2024540209 hasConceptScore W2024540209C86803240 @default.
- W2024540209 hasConceptScore W2024540209C99454951 @default.
- W2024540209 hasLocation W20245402091 @default.
- W2024540209 hasOpenAccess W2024540209 @default.
- W2024540209 hasPrimaryLocation W20245402091 @default.
- W2024540209 hasRelatedWork W1968702905 @default.
- W2024540209 hasRelatedWork W2003356174 @default.
- W2024540209 hasRelatedWork W2008833784 @default.
- W2024540209 hasRelatedWork W2026736483 @default.
- W2024540209 hasRelatedWork W2030117176 @default.
- W2024540209 hasRelatedWork W2036598566 @default.
- W2024540209 hasRelatedWork W2057557065 @default.
- W2024540209 hasRelatedWork W2089703083 @default.
- W2024540209 hasRelatedWork W2105950992 @default.
- W2024540209 hasRelatedWork W2186793740 @default.
- W2024540209 hasVolume "21" @default.
- W2024540209 isParatext "false" @default.
- W2024540209 isRetracted "false" @default.
- W2024540209 magId "2024540209" @default.
- W2024540209 workType "article" @default.