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- W2024543492 endingPage "R909" @default.
- W2024543492 startingPage "R898" @default.
- W2024543492 abstract "The last decade has seen major progress at all levels of neuroscience, from genes and molecules up to integrated systems-level models of brain function. In particular, there have been advances in the understanding of cell-type-specific contributions to function, together with a clearer account of how these contributions are coordinated from moment to moment to organise behavior. A major current endeavor is to leverage this knowledge to develop new therapeutic approaches. In Parkinson's disease, there are a number of promising emerging treatments. Here, we will highlight three ambitious novel therapeutic approaches for this condition, each robustly driven by primary neuroscience. Pharmacogenetics genetically re-engineers neurons to produce neurotrophins that are neuroprotective to vulnerable dopaminergic cells or to directly replace dopamine through enzyme transduction. Deep brain stimulation (DBS) is undergoing a transformation, with adaptive DBS controlled by neural signals resulting in better motor outcomes and significant reductions in overall stimulation that could reduce side effects. Finally, optogenetics presents the opportunity to achieve cell-type-specific control with a high temporal specification on a large enough scale to effectively repair network-level dysfunction." @default.
- W2024543492 created "2016-06-24" @default.
- W2024543492 creator A5058848174 @default.
- W2024543492 creator A5087477752 @default.
- W2024543492 date "2014-09-01" @default.
- W2024543492 modified "2023-09-29" @default.
- W2024543492 title "Focusing Brain Therapeutic Interventions in Space and Time for Parkinson’s Disease" @default.
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