FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024543908> ?p ?o ?g. }

• W2024543908 endingPage "7162" @default.
• W2024543908 startingPage "7157" @default.
• W2024543908 abstract "In the cilia of the nematode Caenorhabditis elegans , anterograde intraflagellar transport (IFT) is mediated by two kinesin-2 complexes, kinesin II and OSM-3 kinesin. These complexes function together in the cilia middle segments, whereas OSM-3 alone mediates transport in the distal segments. Not much is known about the mechanisms that compartmentalize the kinesin-2 complexes or how transport by both kinesins is coordinated. Here, we identify DYF-5, a conserved MAP kinase that plays a role in these processes. Fluorescence microscopy and EM revealed that the cilia of dyf-5 loss-of-function (lf) animals are elongated and are not properly aligned into the amphid channel. Some cilia do enter the amphid channel, but the distal ends of these cilia show accumulation of proteins. Consistent with these observations, we found that six IFT proteins accumulate in the cilia of dyf-5(lf) mutants. In addition, using genetic analyses and live imaging to measure the motility of IFT proteins, we show that dyf-5 is required to restrict kinesin II to the cilia middle segments. Finally, we show that, in dyf-5(lf) mutants, OSM-3 moves at a reduced speed and is not attached to IFT particles. We propose that DYF-5 plays a role in the undocking of kinesin II from IFT particles and in the docking of OSM-3 onto IFT particles." @default.
• W2024543908 created "2016-06-24" @default.
• W2024543908 creator A5000168826 @default.
• W2024543908 creator A5024269155 @default.
• W2024543908 creator A5028883621 @default.
• W2024543908 creator A5038917161 @default.
• W2024543908 creator A5042721662 @default.
• W2024543908 creator A5083637249 @default.
• W2024543908 date "2007-04-24" @default.
• W2024543908 modified "2023-10-01" @default.
• W2024543908 title "Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of <i>Caenorhabditis elegans</i>" @default.
• W2024543908 cites W118771962 @default.
• W2024543908 cites W1554974851 @default.
• W2024543908 cites W1881608452 @default.
• W2024543908 cites W1921149115 @default.
• W2024543908 cites W1982003147 @default.
• W2024543908 cites W1990195067 @default.
• W2024543908 cites W1994256779 @default.
• W2024543908 cites W1999022290 @default.
• W2024543908 cites W2000068229 @default.
• W2024543908 cites W2000860920 @default.
• W2024543908 cites W2001047457 @default.
• W2024543908 cites W2005619876 @default.
• W2024543908 cites W2006130293 @default.
• W2024543908 cites W2010673809 @default.
• W2024543908 cites W2031240463 @default.
• W2024543908 cites W2044969851 @default.
• W2024543908 cites W2046320664 @default.
• W2024543908 cites W2046746554 @default.
• W2024543908 cites W2051440844 @default.
• W2024543908 cites W2057104531 @default.
• W2024543908 cites W2064925044 @default.
• W2024543908 cites W2070969331 @default.
• W2024543908 cites W2073745454 @default.
• W2024543908 cites W2075495332 @default.
• W2024543908 cites W2076488684 @default.
• W2024543908 cites W2090768555 @default.
• W2024543908 cites W2093726901 @default.
• W2024543908 cites W2110400755 @default.
• W2024543908 cites W2112200758 @default.
• W2024543908 cites W2116079099 @default.
• W2024543908 cites W2134780731 @default.
• W2024543908 cites W2136146731 @default.
• W2024543908 cites W2137095157 @default.
• W2024543908 cites W2142573754 @default.
• W2024543908 cites W2145300367 @default.
• W2024543908 cites W2149003185 @default.
• W2024543908 cites W2152523782 @default.
• W2024543908 cites W2160938187 @default.
• W2024543908 cites W2161369215 @default.
• W2024543908 cites W2162893660 @default.
• W2024543908 cites W2165744297 @default.
• W2024543908 cites W2166977115 @default.
• W2024543908 cites W4211143281 @default.
• W2024543908 cites W4246673719 @default.
• W2024543908 cites W4251862424 @default.
• W2024543908 doi "https://doi.org/10.1073/pnas.0606974104" @default.
• W2024543908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1855366" @default.
• W2024543908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17420466" @default.
• W2024543908 hasPublicationYear "2007" @default.
• W2024543908 type Work @default.
• W2024543908 sameAs 2024543908 @default.
• W2024543908 citedByCount "110" @default.
• W2024543908 countsByYear W20245439082012 @default.
• W2024543908 countsByYear W20245439082013 @default.
• W2024543908 countsByYear W20245439082014 @default.
• W2024543908 countsByYear W20245439082015 @default.
• W2024543908 countsByYear W20245439082016 @default.
• W2024543908 countsByYear W20245439082017 @default.
• W2024543908 countsByYear W20245439082018 @default.
• W2024543908 countsByYear W20245439082019 @default.
• W2024543908 countsByYear W20245439082020 @default.
• W2024543908 countsByYear W20245439082021 @default.
• W2024543908 countsByYear W20245439082022 @default.
• W2024543908 countsByYear W20245439082023 @default.
• W2024543908 crossrefType "journal-article" @default.
• W2024543908 hasAuthorship W2024543908A5000168826 @default.
• W2024543908 hasAuthorship W2024543908A5024269155 @default.
• W2024543908 hasAuthorship W2024543908A5028883621 @default.
• W2024543908 hasAuthorship W2024543908A5038917161 @default.
• W2024543908 hasAuthorship W2024543908A5042721662 @default.
• W2024543908 hasAuthorship W2024543908A5083637249 @default.
• W2024543908 hasBestOaLocation W20245439082 @default.
• W2024543908 hasConcept C100094513 @default.
• W2024543908 hasConcept C104317684 @default.
• W2024543908 hasConcept C115811362 @default.
• W2024543908 hasConcept C20418707 @default.
• W2024543908 hasConcept C2778944004 @default.
• W2024543908 hasConcept C37590093 @default.
• W2024543908 hasConcept C54355233 @default.
• W2024543908 hasConcept C58207958 @default.
• W2024543908 hasConcept C59006786 @default.
• W2024543908 hasConcept C86803240 @default.
• W2024543908 hasConcept C93126451 @default.
• W2024543908 hasConcept C95444343 @default.
• W2024543908 hasConceptScore W2024543908C100094513 @default.
• W2024543908 hasConceptScore W2024543908C104317684 @default.
• W2024543908 hasConceptScore W2024543908C115811362 @default.

• next