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- W2024546017 abstract "The aggregation of blood platelets is a crucial step in normal hemostasis for all mammals. Circulating platelets are sensitive to a large variety of physiologic and non-physiologic stimulants, some of which are formed or exposed in conjunction with vascular damage or endothelial cell denudation. In addition, drastic pressure changes activate human platelets. Killer whale platelet function, on the other hand, is very intriguing since these animals do not seem to experience untoward platelet reactions during or after diving to great depths, nor do they experience abnormal bleeding associated with sub optimal platelet function. We examined this concept and determined that killer whale platelets, in response to ADP, PAF, and arachidonic acid, appeared to aggregate normally during the first 2–5 minutes after addition of the agonist, but had completely disaggregated at 10 minutes. Collagen- and A23187-induced aggregation appeared normal and complete within 10 minutes, while there was no response to epinephrine or ristocetin. Thromboxane production by killer whale platelets appears to be quantitatively similar to that produced by human platelets in response to ADP and PAF and exceeded that produced by human platelets when collagen was used as the agonist. In summary, this study reports a reduced platelet aggregation reaction in killer whales in response to several platelet agonists which does not appear to be related to the generation of thromboxane. This phenomenon may serve a protective role in these mammals by preventing thrombosis during diving and resurfacing." @default.
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- W2024546017 date "1993-05-01" @default.
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- W2024546017 title "Aggregation of killer whale platelets" @default.
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- W2024546017 doi "https://doi.org/10.1016/0049-3848(93)90129-c" @default.
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