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- W2024551462 abstract "Aphidicolin, a tetracyclic diterpenoid, is known to be antiviral and to inhibit the incorporation of thymidine into DNA of cultured human embryonic lung cells. We examined effects of the compound on the activity of several DNA polymerases obtained from subcellular fractions of rat liver. Aphidicolin at a concentration of 15 μg/ml caused a 85% reduction in level of the activity of crude and partially purified DNA polymerases from the cytosol. However, aphidicolin even at a concentration of 75 μg/ml failed to affect the activity of crude and partially purified DNA polymerases from nuclear and mitochondrial fractions." @default.
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- W2024551462 date "1978-06-01" @default.
- W2024551462 modified "2023-10-16" @default.
- W2024551462 title "Aphidicolin: A specific inhibitor of DNA polymerases in the cytosol of rat liver" @default.
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- W2024551462 doi "https://doi.org/10.1016/0006-291x(78)90298-x" @default.
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