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• W2024552999 abstract "Amyloid is the name given to a special type of linear protein aggregate that exhibits a common set of structural features and dye binding capabilities. The formation of amyloid is associated with over 27 distinct human diseases which are collectively referred to as the amyloidoses. Although there is great diversity amongst the amyloidoses with regard to the polypeptide monomeric precursor, targeted tissues, and the nature and time course of disease development, the common underlying link of a structurally similar amyloid aggregate has prompted the search for a unified theory of disease progression in which amyloid production is the central element. Computational modeling has allowed the formulation and testing of scientific hypotheses for exploring this relationship. However, the majority of computational studies on amyloid aggregation are pitched at the atomistic level of description, in simple ideal solution environments, with simulation time scales of the order of microseconds and system sizes limited to 100 monomers (or fewer). The experimental reality is that disease-related amyloid aggregation processes occur in extremely complex reaction environments (i.e. the human body), over time scales of months to years with monitoring of the reaction achieved using extremely coarse or indirect experimental markers that yield little or no atomistic insight. Clearly, a substantial gap exists between computational and experimental communities with a deficit of ‘useful’ computational methodology that can be directly related to available markers of disease progression. This review will place its focus on the development of these latter types of computational models and discuss them in relation to disease onset and progression." @default.
• W2024552999 created "2016-06-24" @default.
• W2024552999 creator A5005390814 @default.
• W2024552999 creator A5060978742 @default.
• W2024552999 date "2012-09-01" @default.
• W2024552999 modified "2023-10-14" @default.
• W2024552999 title "Computational modeling of the relationship between amyloid and disease" @default.
• W2024552999 cites W1480950303 @default.
• W2024552999 cites W1485459398 @default.
• W2024552999 cites W1500540324 @default.
• W2024552999 cites W1532138628 @default.
• W2024552999 cites W1549251788 @default.
• W2024552999 cites W1553457312 @default.
• W2024552999 cites W1576709629 @default.
• W2024552999 cites W1603276818 @default.
• W2024552999 cites W1745084828 @default.
• W2024552999 cites W1773701686 @default.
• W2024552999 cites W1894729831 @default.
• W2024552999 cites W1965420960 @default.
• W2024552999 cites W1967656174 @default.
• W2024552999 cites W1970505320 @default.
• W2024552999 cites W1970946380 @default.
• W2024552999 cites W1972011321 @default.
• W2024552999 cites W1974790276 @default.
• W2024552999 cites W1975315404 @default.
• W2024552999 cites W1979355017 @default.
• W2024552999 cites W1982352389 @default.
• W2024552999 cites W1983367752 @default.
• W2024552999 cites W1983387292 @default.
• W2024552999 cites W1983998410 @default.
• W2024552999 cites W1985613997 @default.
• W2024552999 cites W1988089792 @default.
• W2024552999 cites W1989150559 @default.
• W2024552999 cites W1989252530 @default.
• W2024552999 cites W1990268360 @default.
• W2024552999 cites W1991659188 @default.
• W2024552999 cites W1992485812 @default.
• W2024552999 cites W1995247791 @default.
• W2024552999 cites W1995496955 @default.
• W2024552999 cites W1995851835 @default.
• W2024552999 cites W1997525726 @default.
• W2024552999 cites W1997938990 @default.
• W2024552999 cites W2001591118 @default.
• W2024552999 cites W2002614840 @default.
• W2024552999 cites W2004098528 @default.
• W2024552999 cites W2005212584 @default.
• W2024552999 cites W2006510253 @default.
• W2024552999 cites W2006654567 @default.
• W2024552999 cites W2006813423 @default.
• W2024552999 cites W2009531026 @default.
• W2024552999 cites W2010476270 @default.
• W2024552999 cites W2010864265 @default.
• W2024552999 cites W2012223842 @default.
• W2024552999 cites W2012436507 @default.
• W2024552999 cites W2012561243 @default.
• W2024552999 cites W2015234786 @default.
• W2024552999 cites W2015675204 @default.
• W2024552999 cites W2016166584 @default.
• W2024552999 cites W2018852249 @default.
• W2024552999 cites W2023096029 @default.
• W2024552999 cites W2026306293 @default.
• W2024552999 cites W2028796380 @default.
• W2024552999 cites W2031943657 @default.
• W2024552999 cites W2033182544 @default.
• W2024552999 cites W2033230621 @default.
• W2024552999 cites W2034170455 @default.
• W2024552999 cites W2034408997 @default.
• W2024552999 cites W2037298718 @default.
• W2024552999 cites W2039516928 @default.
• W2024552999 cites W2040675166 @default.
• W2024552999 cites W2042996975 @default.
• W2024552999 cites W2043351249 @default.
• W2024552999 cites W2043775177 @default.
• W2024552999 cites W2046576999 @default.
• W2024552999 cites W2046634028 @default.
• W2024552999 cites W2052149626 @default.
• W2024552999 cites W2054544406 @default.
• W2024552999 cites W2054942361 @default.
• W2024552999 cites W2057709942 @default.
• W2024552999 cites W2057828823 @default.
• W2024552999 cites W2058825829 @default.
• W2024552999 cites W2059804089 @default.
• W2024552999 cites W2061008485 @default.
• W2024552999 cites W2061627162 @default.
• W2024552999 cites W2062593465 @default.
• W2024552999 cites W2063838503 @default.
• W2024552999 cites W2064187550 @default.
• W2024552999 cites W2064367582 @default.
• W2024552999 cites W2064931700 @default.
• W2024552999 cites W2066083611 @default.
• W2024552999 cites W2066987474 @default.
• W2024552999 cites W2072838719 @default.
• W2024552999 cites W2073009405 @default.
• W2024552999 cites W2073394015 @default.
• W2024552999 cites W2074542471 @default.
• W2024552999 cites W2076586844 @default.
• W2024552999 cites W2077858999 @default.
• W2024552999 cites W2078637793 @default.

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