FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024553502> ?p ?o ?g. }

• W2024553502 endingPage "883" @default.
• W2024553502 startingPage "873" @default.
• W2024553502 abstract "Gloriosaols A-C, isolated from Yucca gloriosa (Agavaceae), are novel phenolic compounds structurally related to resveratrol. In the present study, we show that gloriosaols possess antiproliferative and pro-apoptotic activity on tumor cells of different histogenetic origin and that their cell growth inhibition potential is higher than that of resveratrol. Despite the close similarities in their structure, gloriosaols A-C exhibited different antiproliferative potency, as the EC(50) ascending order is: gloriosaol C, gloriosaol A, gloriosaol B. Further mechanisms of gloriosaol C cytotoxicity were elucidated in detail in U937 cells, the most sensitive of the cell lines tested. The effect of gloriosaol C on cell growth turned out to be strongly dependent upon the concentration. Gloriosaol C doses lower than the EC(50) value (8 mu-icroM) blocked the cell cycle in G(0)/G(1), with a concurrent decrease in the number of cells in the G(2)/M phases of the cell cycle. At higher doses, this arrest overlaps with the occurrence of apoptosis and necrosis. In the 10-25 microM range of doses, gloriosaol C caused cell death mainly by apoptosis, as measured by hypodiploidia induction, phosphatidyl serine externalization and disruption of mitochondrial transmembrane potential. A switch in the mode of death from apoptosis to necrosis occurred at doses of gloriosaol C higher than 30 microM. Gloriosaol C was found to induce production of reactive species dose-dependently, but also to counteract their elevation in stressed cells. Thus, the different fate of cells, that is cell cycle arrest or cell death, in response to different doses of gloriosaol C might be related to the extent of induced oxidative stress." @default.
• W2024553502 created "2016-06-24" @default.
• W2024553502 creator A5001382285 @default.
• W2024553502 creator A5015973876 @default.
• W2024553502 creator A5031056335 @default.
• W2024553502 creator A5031670725 @default.
• W2024553502 creator A5052604099 @default.
• W2024553502 creator A5058213300 @default.
• W2024553502 creator A5075332167 @default.
• W2024553502 creator A5087056070 @default.
• W2024553502 date "2007-08-01" @default.
• W2024553502 modified "2023-10-16" @default.
• W2024553502 title "Antiproliferative and pro-apoptotic activity of novel phenolic derivatives of resveratrol" @default.
• W2024553502 cites W1574058927 @default.
• W2024553502 cites W1595815978 @default.
• W2024553502 cites W1640635403 @default.
• W2024553502 cites W1968599399 @default.
• W2024553502 cites W1974573122 @default.
• W2024553502 cites W1979129905 @default.
• W2024553502 cites W1979501382 @default.
• W2024553502 cites W1991253583 @default.
• W2024553502 cites W1999605572 @default.
• W2024553502 cites W2009183786 @default.
• W2024553502 cites W2012025231 @default.
• W2024553502 cites W2015200132 @default.
• W2024553502 cites W2019660215 @default.
• W2024553502 cites W2031324765 @default.
• W2024553502 cites W2034915619 @default.
• W2024553502 cites W2037461711 @default.
• W2024553502 cites W2045577426 @default.
• W2024553502 cites W2049110705 @default.
• W2024553502 cites W2050263998 @default.
• W2024553502 cites W2066313395 @default.
• W2024553502 cites W2069204745 @default.
• W2024553502 cites W2072781790 @default.
• W2024553502 cites W2078532650 @default.
• W2024553502 cites W2088011557 @default.
• W2024553502 cites W2088542645 @default.
• W2024553502 cites W2089663038 @default.
• W2024553502 cites W2108300681 @default.
• W2024553502 cites W2136138495 @default.
• W2024553502 cites W2158373947 @default.
• W2024553502 cites W2171519440 @default.
• W2024553502 cites W2172249877 @default.
• W2024553502 cites W2188526507 @default.
• W2024553502 cites W2750896950 @default.
• W2024553502 cites W2952079882 @default.
• W2024553502 cites W3004118171 @default.
• W2024553502 cites W4235996718 @default.
• W2024553502 doi "https://doi.org/10.1016/j.lfs.2007.07.010" @default.
• W2024553502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17764700" @default.
• W2024553502 hasPublicationYear "2007" @default.
• W2024553502 type Work @default.
• W2024553502 sameAs 2024553502 @default.
• W2024553502 citedByCount "18" @default.
• W2024553502 countsByYear W20245535022012 @default.
• W2024553502 countsByYear W20245535022014 @default.
• W2024553502 countsByYear W20245535022015 @default.
• W2024553502 countsByYear W20245535022018 @default.
• W2024553502 countsByYear W20245535022019 @default.
• W2024553502 countsByYear W20245535022022 @default.
• W2024553502 countsByYear W20245535022023 @default.
• W2024553502 crossrefType "journal-article" @default.
• W2024553502 hasAuthorship W2024553502A5001382285 @default.
• W2024553502 hasAuthorship W2024553502A5015973876 @default.
• W2024553502 hasAuthorship W2024553502A5031056335 @default.
• W2024553502 hasAuthorship W2024553502A5031670725 @default.
• W2024553502 hasAuthorship W2024553502A5052604099 @default.
• W2024553502 hasAuthorship W2024553502A5058213300 @default.
• W2024553502 hasAuthorship W2024553502A5075332167 @default.
• W2024553502 hasAuthorship W2024553502A5087056070 @default.
• W2024553502 hasConcept C105696609 @default.
• W2024553502 hasConcept C109316439 @default.
• W2024553502 hasConcept C1491633281 @default.
• W2024553502 hasConcept C185592680 @default.
• W2024553502 hasConcept C190283241 @default.
• W2024553502 hasConcept C202751555 @default.
• W2024553502 hasConcept C2776816829 @default.
• W2024553502 hasConcept C29537977 @default.
• W2024553502 hasConcept C31573885 @default.
• W2024553502 hasConcept C503630168 @default.
• W2024553502 hasConcept C54355233 @default.
• W2024553502 hasConcept C55493867 @default.
• W2024553502 hasConcept C62112901 @default.
• W2024553502 hasConcept C81885089 @default.
• W2024553502 hasConcept C86803240 @default.
• W2024553502 hasConcept C95444343 @default.
• W2024553502 hasConceptScore W2024553502C105696609 @default.
• W2024553502 hasConceptScore W2024553502C109316439 @default.
• W2024553502 hasConceptScore W2024553502C1491633281 @default.
• W2024553502 hasConceptScore W2024553502C185592680 @default.
• W2024553502 hasConceptScore W2024553502C190283241 @default.
• W2024553502 hasConceptScore W2024553502C202751555 @default.
• W2024553502 hasConceptScore W2024553502C2776816829 @default.
• W2024553502 hasConceptScore W2024553502C29537977 @default.
• W2024553502 hasConceptScore W2024553502C31573885 @default.
• W2024553502 hasConceptScore W2024553502C503630168 @default.
• W2024553502 hasConceptScore W2024553502C54355233 @default.

• next