FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024553605> ?p ?o ?g. }

• W2024553605 endingPage "354" @default.
• W2024553605 startingPage "346" @default.
• W2024553605 abstract "Bacteroides fragilis is a human gut commensal and an opportunistic pathogen causing anaerobic abscesses and bacteraemias which are treated with metronidazole (Mtz), a DNA damaging agent. This study examined the role of the DNA repair protein, RecA, in maintaining endogenous DNA stability and its contribution to resistance to Mtz and other DNA damaging agents. RT-PCR of B. fragilis genomic DNA showed that the recA gene was co-transcribed as an operon together with two upstream genes, putatively involved in repairing oxygen damage. A B. fragilis recA mutant was generated using targeted gene inactivation. Fluorescence microscopy using DAPI staining revealed increased numbers of mutant cells with reduced intact double-stranded DNA. Alkaline gel electrophoresis of the recA mutant DNA showed increased amounts of strand breaks under normal growth conditions, and the recA mutant also showed less spontaneous mutagenesis relative to the wild type strain. The recA mutant was sensitive to Mtz, ultraviolet light and hydrogen peroxide. A B. fragilis strain overexpressing the RecA protein exhibited increased resistance to Mtz compared to the wild type. This is the first study to show that overexpression of a DNA repair protein in B. fragilis increases Mtz resistance. This represents a novel drug resistance mechanism in this bacterium." @default.
• W2024553605 created "2016-06-24" @default.
• W2024553605 creator A5007407691 @default.
• W2024553605 creator A5039891269 @default.
• W2024553605 creator A5058444714 @default.
• W2024553605 creator A5082375532 @default.
• W2024553605 creator A5083893885 @default.
• W2024553605 creator A5087896347 @default.
• W2024553605 date "2010-06-01" @default.
• W2024553605 modified "2023-10-01" @default.
• W2024553605 title "Bacteroides fragilis RecA protein overexpression causes resistance to metronidazole" @default.
• W2024553605 cites W1552118894 @default.
• W2024553605 cites W1562974039 @default.
• W2024553605 cites W1606015018 @default.
• W2024553605 cites W1903000287 @default.
• W2024553605 cites W1975302271 @default.
• W2024553605 cites W1975982665 @default.
• W2024553605 cites W1983958450 @default.
• W2024553605 cites W1991364432 @default.
• W2024553605 cites W1993616220 @default.
• W2024553605 cites W1996080772 @default.
• W2024553605 cites W2004589024 @default.
• W2024553605 cites W2004757024 @default.
• W2024553605 cites W2008136734 @default.
• W2024553605 cites W2008201158 @default.
• W2024553605 cites W2022559772 @default.
• W2024553605 cites W2022729339 @default.
• W2024553605 cites W2026490998 @default.
• W2024553605 cites W2027229485 @default.
• W2024553605 cites W2028622989 @default.
• W2024553605 cites W2042050496 @default.
• W2024553605 cites W2042845004 @default.
• W2024553605 cites W2046204981 @default.
• W2024553605 cites W2047201070 @default.
• W2024553605 cites W2048205908 @default.
• W2024553605 cites W2070937172 @default.
• W2024553605 cites W2072792818 @default.
• W2024553605 cites W2076108928 @default.
• W2024553605 cites W2076712367 @default.
• W2024553605 cites W2092463196 @default.
• W2024553605 cites W2101852702 @default.
• W2024553605 cites W2109836043 @default.
• W2024553605 cites W2117971620 @default.
• W2024553605 cites W2119459218 @default.
• W2024553605 cites W2125947686 @default.
• W2024553605 cites W2126636532 @default.
• W2024553605 cites W2128578806 @default.
• W2024553605 cites W2129153689 @default.
• W2024553605 cites W2131919079 @default.
• W2024553605 cites W2133290100 @default.
• W2024553605 cites W2143868758 @default.
• W2024553605 cites W2148680617 @default.
• W2024553605 cites W2149456142 @default.
• W2024553605 cites W2152547850 @default.
• W2024553605 cites W2158714788 @default.
• W2024553605 cites W2163775725 @default.
• W2024553605 cites W2170164699 @default.
• W2024553605 doi "https://doi.org/10.1016/j.resmic.2010.04.003" @default.
• W2024553605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3025348" @default.
• W2024553605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20435137" @default.
• W2024553605 hasPublicationYear "2010" @default.
• W2024553605 type Work @default.
• W2024553605 sameAs 2024553605 @default.
• W2024553605 citedByCount "55" @default.
• W2024553605 countsByYear W20245536052012 @default.
• W2024553605 countsByYear W20245536052013 @default.
• W2024553605 countsByYear W20245536052014 @default.
• W2024553605 countsByYear W20245536052015 @default.
• W2024553605 countsByYear W20245536052016 @default.
• W2024553605 countsByYear W20245536052017 @default.
• W2024553605 countsByYear W20245536052018 @default.
• W2024553605 countsByYear W20245536052019 @default.
• W2024553605 countsByYear W20245536052020 @default.
• W2024553605 countsByYear W20245536052021 @default.
• W2024553605 countsByYear W20245536052022 @default.
• W2024553605 countsByYear W20245536052023 @default.
• W2024553605 crossrefType "journal-article" @default.
• W2024553605 hasAuthorship W2024553605A5007407691 @default.
• W2024553605 hasAuthorship W2024553605A5039891269 @default.
• W2024553605 hasAuthorship W2024553605A5058444714 @default.
• W2024553605 hasAuthorship W2024553605A5082375532 @default.
• W2024553605 hasAuthorship W2024553605A5083893885 @default.
• W2024553605 hasAuthorship W2024553605A5087896347 @default.
• W2024553605 hasBestOaLocation W20245536051 @default.
• W2024553605 hasConcept C104317684 @default.
• W2024553605 hasConcept C134935766 @default.
• W2024553605 hasConcept C143065580 @default.
• W2024553605 hasConcept C143425029 @default.
• W2024553605 hasConcept C153911025 @default.
• W2024553605 hasConcept C16318435 @default.
• W2024553605 hasConcept C2780246119 @default.
• W2024553605 hasConcept C2780852648 @default.
• W2024553605 hasConcept C501593827 @default.
• W2024553605 hasConcept C552990157 @default.
• W2024553605 hasConcept C55493867 @default.
• W2024553605 hasConcept C86803240 @default.
• W2024553605 hasConcept C89423630 @default.
• W2024553605 hasConceptScore W2024553605C104317684 @default.

• next