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• W2024553614 abstract "Ranaviruses like frog virus 3 (FV3) are responsible for emerging infectious diseases spreading worldwide to fish, amphibian and reptilian species. We have developed, in Xenopus laevis, an experimental model to investigate viral transmission. We show that FV3 released in water by immunocompromised infected adults can infect adult and larval stages of Xenopus within 3 h of exposure. Time course of virus load and viral transcription in different tissues suggests that early waterborne FV3 infection through the digestive tract leads to dissemination in the kidney. Finally, a fraction of adult macrophages becomes infected following exposure to waterborne FV3 as visualized by fluorescence microscopy using macrophage- and FV3-specific antibodies. Little cytopathicity and apoptosis were detected in infected macrophages, which is consistent with our proposition that macrophages are permissive to FV3. These data highlight the efficiency of FV3 infectivity by the water route and the ability of FV3 to adapt to its hosts." @default.
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• W2024553614 date "2011-09-01" @default.
• W2024553614 modified "2023-10-14" @default.
• W2024553614 title "Waterborne infectivity of the Ranavirus frog virus 3 in Xenopus laevis" @default.
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• W2024553614 doi "https://doi.org/10.1016/j.virol.2011.06.026" @default.
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