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• W2024554233 startingPage "441" @default.
• W2024554233 abstract "The primary and specific function of the osteoclast is the resorption of bone. We have applied this criterion, and a monoclonal antibody that binds specifically to osteoclasts, to cultures of tissues that may contain osteoclastic precursors. Bone marrow and spleen cells were incubated for up to 4 weeks in the presence or absence of parathyroid hormone, interleukin 1, or 1,25(OH)2 vitamin D3, on plastic coverslips or slices of devitalised bone. Osteoclasts (as judged by the presence of resorption cavities and the appearance of monoclonal antibody-positive cells) did not develop in cultures incubated without added hormones, nor in cultures containing parathyroid hormone or interleukin 1, but were regularly observed when bone marrow cells were incubated with 1,25(OH)2 vitamin D3. Although multinucleate giant cells were common after incubation, especially in the presence 1,25(OH)2 vitamin D3, monoclonal antibody bound not to these cells but to a minor and distinctive population of mononuclear cells and cells of low multinuclearity. We found no excavations and no monoclonal antibody-positive cells after incubation of peritoneal macrophages with 1,25(OH)2D3. These results provide direct evidence of osteoclastic function arising in cultures of haemopoietic tissues." @default.
• W2024554233 created "2016-06-24" @default.
• W2024554233 creator A5022543438 @default.
• W2024554233 creator A5073697395 @default.
• W2024554233 date "1987-09-01" @default.
• W2024554233 modified "2023-09-23" @default.
• W2024554233 title "Generation of osteoclasts in cultures of rabbit bone marrow and spleen cells" @default.
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• W2024554233 doi "https://doi.org/10.1002/jcp.1041320306" @default.
• W2024554233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3308907" @default.
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