FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024554713> ?p ?o ?g. }

• W2024554713 endingPage "327" @default.
• W2024554713 startingPage "321" @default.
• W2024554713 abstract "Summary: Purpose: The purpose of this study was to evaluate in mice the anticonvulsant potential of N ‐palmitoylethanolamide, a putative endocannabinoid that accumulates in the body during inflammatory processes. Methods: N ‐palmitoylethanolamide was injected intraperitoneally (i.p.) in mice and evaluated for anticonvulsant activity [in maximal electroshock seizure (MES) and chemical‐induced convulsions] and for neurologic impairment (rotorod). It was compared with anandamide and with different palmitic acid analogues as well as with reference anticonvulsants (AEDs) injected under the same conditions. Results: The MES test showed, after i.p. administration to mice, that N ‐ palmitoylethanolamide had an median effective dose (ED 50 ) value comparable to that of phenytoin (PHT; 8.9 and 9.2 mg/kg, respectively). In the subcutaneous pentylenetetrazol test and in the 3‐mercaptropropionic acid test, it was effective only against tonic convulsions. N ‐palmitoylethanolamide was devoid of neurologic impairment ≤250 mg/kg, yielding a high protective index. Conclusions: N ‐palmitoylethanolamide, an endogenous compound with antiinflammatory and analgesic activities, is a potent AED in mice. Its precise mechanism of action remains to be elucidated." @default.
• W2024554713 created "2016-06-24" @default.
• W2024554713 creator A5001542550 @default.
• W2024554713 creator A5021952398 @default.
• W2024554713 creator A5039045828 @default.
• W2024554713 creator A5051675396 @default.
• W2024554713 creator A5054325844 @default.
• W2024554713 date "2001-03-09" @default.
• W2024554713 modified "2023-10-16" @default.
• W2024554713 title "Anticonvulsant Activity of N-Palmitoylethanolamide, a Putative Endocannabinoid, in Mice" @default.
• W2024554713 cites W109761354 @default.
• W2024554713 cites W1572519545 @default.
• W2024554713 cites W1651476949 @default.
• W2024554713 cites W1964000278 @default.
• W2024554713 cites W1964106579 @default.
• W2024554713 cites W1966451239 @default.
• W2024554713 cites W1975161769 @default.
• W2024554713 cites W1989073099 @default.
• W2024554713 cites W1993811439 @default.
• W2024554713 cites W1995152060 @default.
• W2024554713 cites W1998941878 @default.
• W2024554713 cites W2000082939 @default.
• W2024554713 cites W2000361888 @default.
• W2024554713 cites W2002921724 @default.
• W2024554713 cites W2010630369 @default.
• W2024554713 cites W2015080435 @default.
• W2024554713 cites W2024009202 @default.
• W2024554713 cites W2027918315 @default.
• W2024554713 cites W2031071131 @default.
• W2024554713 cites W2031406492 @default.
• W2024554713 cites W2039280899 @default.
• W2024554713 cites W2042544913 @default.
• W2024554713 cites W2045676110 @default.
• W2024554713 cites W2046614626 @default.
• W2024554713 cites W2058766482 @default.
• W2024554713 cites W2060843720 @default.
• W2024554713 cites W2069602605 @default.
• W2024554713 cites W2095179507 @default.
• W2024554713 cites W2111276435 @default.
• W2024554713 cites W2119898593 @default.
• W2024554713 cites W2135253454 @default.
• W2024554713 cites W2144898517 @default.
• W2024554713 cites W2170556110 @default.
• W2024554713 cites W2323471917 @default.
• W2024554713 cites W2806680074 @default.
• W2024554713 cites W4292304406 @default.
• W2024554713 cites W4297818596 @default.
• W2024554713 doi "https://doi.org/10.1046/j.1528-1157.2001.41499.x" @default.
• W2024554713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11442148" @default.
• W2024554713 hasPublicationYear "2001" @default.
• W2024554713 type Work @default.
• W2024554713 sameAs 2024554713 @default.
• W2024554713 citedByCount "126" @default.
• W2024554713 countsByYear W20245547132012 @default.
• W2024554713 countsByYear W20245547132013 @default.
• W2024554713 countsByYear W20245547132014 @default.
• W2024554713 countsByYear W20245547132015 @default.
• W2024554713 countsByYear W20245547132016 @default.
• W2024554713 countsByYear W20245547132017 @default.
• W2024554713 countsByYear W20245547132018 @default.
• W2024554713 countsByYear W20245547132019 @default.
• W2024554713 countsByYear W20245547132020 @default.
• W2024554713 countsByYear W20245547132021 @default.
• W2024554713 countsByYear W20245547132022 @default.
• W2024554713 countsByYear W20245547132023 @default.
• W2024554713 crossrefType "journal-article" @default.
• W2024554713 hasAuthorship W2024554713A5001542550 @default.
• W2024554713 hasAuthorship W2024554713A5021952398 @default.
• W2024554713 hasAuthorship W2024554713A5039045828 @default.
• W2024554713 hasAuthorship W2024554713A5051675396 @default.
• W2024554713 hasAuthorship W2024554713A5054325844 @default.
• W2024554713 hasBestOaLocation W20245547131 @default.
• W2024554713 hasConcept C118552586 @default.
• W2024554713 hasConcept C126322002 @default.
• W2024554713 hasConcept C148001335 @default.
• W2024554713 hasConcept C170493617 @default.
• W2024554713 hasConcept C185592680 @default.
• W2024554713 hasConcept C2775858608 @default.
• W2024554713 hasConcept C2776819090 @default.
• W2024554713 hasConcept C2776885963 @default.
• W2024554713 hasConcept C2776895053 @default.
• W2024554713 hasConcept C2777056318 @default.
• W2024554713 hasConcept C2777767828 @default.
• W2024554713 hasConcept C2778186239 @default.
• W2024554713 hasConcept C2779783865 @default.
• W2024554713 hasConcept C2780871563 @default.
• W2024554713 hasConcept C46721173 @default.
• W2024554713 hasConcept C71924100 @default.
• W2024554713 hasConcept C98274493 @default.
• W2024554713 hasConceptScore W2024554713C118552586 @default.
• W2024554713 hasConceptScore W2024554713C126322002 @default.
• W2024554713 hasConceptScore W2024554713C148001335 @default.
• W2024554713 hasConceptScore W2024554713C170493617 @default.
• W2024554713 hasConceptScore W2024554713C185592680 @default.
• W2024554713 hasConceptScore W2024554713C2775858608 @default.
• W2024554713 hasConceptScore W2024554713C2776819090 @default.
• W2024554713 hasConceptScore W2024554713C2776885963 @default.
• W2024554713 hasConceptScore W2024554713C2776895053 @default.

• next