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- W2024554893 abstract "1-Methylisoguanosine is a marine natural product with skeletal muscle relaxant, hypothermic and cardiovascular effects following oral administration in mice and rats. The cardiovascular effects (hypotension associated with bradycardia) are similar to those of adenosine. Structure-activity studies with a series of 1-methylisoguanosine analogues suggest a reasonable correlation between ability of the compounds to stimulate adenosine-sensitive adenylate cyclase and effects on skeletal muscular and cardiovascular responses. Thus, it appears that 1-methylisoguanosine may function as a long-acting adenosine analogue." @default.
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- W2024554893 date "1980-03-01" @default.
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- W2024554893 title "1-Methylisoguanosine: An orally active marine natural product with skeletal muscle and cardiovascular effects" @default.
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- W2024554893 doi "https://doi.org/10.1016/0024-3205(80)90253-2" @default.
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