FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024555007> ?p ?o ?g. }

• W2024555007 endingPage "335" @default.
• W2024555007 startingPage "331" @default.
• W2024555007 abstract "Panax ginseng C.A. MEYER (Araliaceae), which contains ginsenosides as its main components, has been shown to have various biological effects, including anti-inflammatory, anxiolytic, anti-stress, and anti-tumor effects. Orally administered ginsenoside Rb1 and Re are metabolized to 20(S)-protopanaxadiol (PPD) and compound K via ginsenoside Rd and 20(S)-protopanaxatriol (PPT) and ginsenoside Rh1 via ginsenoside Rg1 by gut microbiota, respectively. Therefore, we investigated the anti-stress effects of these metabolites, PPD and PPT, by measuring their anxiolytic and anti-inflammatory effects in immobilized mice. Treatment with PPD and PPT prior to immobilization stress increased the time spent in open arms and open arm entries in the elevated plus-maze (EPM) test. The anxiolytic effects of PPD (10 mg/kg) and PPT (10 mg/kg) were comparable to that of buspirone (1 mg/kg). This observed anxiolytic effect of PPD was significantly blocked by flumazenil or bicuculline, and the effect of PPT was blocked by WAY-100635. Treatment with PPD also potently suppressed immobilization stress-induced serum levels of corticosterone and interleukin (IL)-6 by the enzyme-linked immunosorbent assay. However, PPT treatment did not suppress them. Based on these findings, PPD and PPT may exhibit the anxiolytic effect via γ-aminobutyrateA (GABAA) receptor(s) and serotonergic receptor(s), respectively, and PPD may have an anti-inflammatory effect that is more potent than that of PPT." @default.
• W2024555007 created "2016-06-24" @default.
• W2024555007 creator A5044174536 @default.
• W2024555007 creator A5052356087 @default.
• W2024555007 creator A5055955541 @default.
• W2024555007 creator A5068897055 @default.
• W2024555007 creator A5072015406 @default.
• W2024555007 date "2015-01-01" @default.
• W2024555007 modified "2023-09-27" @default.
• W2024555007 title "Anti-stress Effects of 20(<i>S</i>)-Protopanaxadiol and 20(<i>S</i>)-Protopanaxatriol in Immobilized Mice" @default.
• W2024555007 cites W1535596025 @default.
• W2024555007 cites W1966322039 @default.
• W2024555007 cites W1967405710 @default.
• W2024555007 cites W1971799963 @default.
• W2024555007 cites W1979943481 @default.
• W2024555007 cites W1983000591 @default.
• W2024555007 cites W1987538872 @default.
• W2024555007 cites W1989794336 @default.
• W2024555007 cites W1990455735 @default.
• W2024555007 cites W1990967931 @default.
• W2024555007 cites W2003779900 @default.
• W2024555007 cites W2006336155 @default.
• W2024555007 cites W2010485769 @default.
• W2024555007 cites W2017050142 @default.
• W2024555007 cites W2022090695 @default.
• W2024555007 cites W2024721825 @default.
• W2024555007 cites W2025679886 @default.
• W2024555007 cites W2035847667 @default.
• W2024555007 cites W2038331423 @default.
• W2024555007 cites W2040141686 @default.
• W2024555007 cites W2043097850 @default.
• W2024555007 cites W2046401757 @default.
• W2024555007 cites W2054812204 @default.
• W2024555007 cites W2064457346 @default.
• W2024555007 cites W2065922695 @default.
• W2024555007 cites W2070955461 @default.
• W2024555007 cites W2082509073 @default.
• W2024555007 cites W2090324718 @default.
• W2024555007 cites W2090329364 @default.
• W2024555007 cites W2110656107 @default.
• W2024555007 cites W2112818206 @default.
• W2024555007 cites W2115188038 @default.
• W2024555007 cites W2115383120 @default.
• W2024555007 cites W2132211535 @default.
• W2024555007 cites W2170165650 @default.
• W2024555007 cites W36352745 @default.
• W2024555007 doi "https://doi.org/10.1248/bpb.b14-00669" @default.
• W2024555007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25747994" @default.
• W2024555007 hasPublicationYear "2015" @default.
• W2024555007 type Work @default.
• W2024555007 sameAs 2024555007 @default.
• W2024555007 citedByCount "37" @default.
• W2024555007 countsByYear W20245550072016 @default.
• W2024555007 countsByYear W20245550072017 @default.
• W2024555007 countsByYear W20245550072018 @default.
• W2024555007 countsByYear W20245550072019 @default.
• W2024555007 countsByYear W20245550072020 @default.
• W2024555007 countsByYear W20245550072021 @default.
• W2024555007 countsByYear W20245550072022 @default.
• W2024555007 countsByYear W20245550072023 @default.
• W2024555007 crossrefType "journal-article" @default.
• W2024555007 hasAuthorship W2024555007A5044174536 @default.
• W2024555007 hasAuthorship W2024555007A5052356087 @default.
• W2024555007 hasAuthorship W2024555007A5055955541 @default.
• W2024555007 hasAuthorship W2024555007A5068897055 @default.
• W2024555007 hasAuthorship W2024555007A5072015406 @default.
• W2024555007 hasBestOaLocation W20245550071 @default.
• W2024555007 hasConcept C118552586 @default.
• W2024555007 hasConcept C134018914 @default.
• W2024555007 hasConcept C142724271 @default.
• W2024555007 hasConcept C168258287 @default.
• W2024555007 hasConcept C170493617 @default.
• W2024555007 hasConcept C173586616 @default.
• W2024555007 hasConcept C185592680 @default.
• W2024555007 hasConcept C204787440 @default.
• W2024555007 hasConcept C2775864247 @default.
• W2024555007 hasConcept C2776539398 @default.
• W2024555007 hasConcept C2777032962 @default.
• W2024555007 hasConcept C2777287423 @default.
• W2024555007 hasConcept C2777765862 @default.
• W2024555007 hasConcept C2778409475 @default.
• W2024555007 hasConcept C2779232237 @default.
• W2024555007 hasConcept C2779790080 @default.
• W2024555007 hasConcept C2780352252 @default.
• W2024555007 hasConcept C2780763569 @default.
• W2024555007 hasConcept C37000724 @default.
• W2024555007 hasConcept C55493867 @default.
• W2024555007 hasConcept C558461103 @default.
• W2024555007 hasConcept C71315377 @default.
• W2024555007 hasConcept C71924100 @default.
• W2024555007 hasConcept C98274493 @default.
• W2024555007 hasConceptScore W2024555007C118552586 @default.
• W2024555007 hasConceptScore W2024555007C134018914 @default.
• W2024555007 hasConceptScore W2024555007C142724271 @default.
• W2024555007 hasConceptScore W2024555007C168258287 @default.
• W2024555007 hasConceptScore W2024555007C170493617 @default.
• W2024555007 hasConceptScore W2024555007C173586616 @default.
• W2024555007 hasConceptScore W2024555007C185592680 @default.

• next