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- W2024556039 abstract "The cytoplasmic Ca2+ concentration (Ca2+i) was measured in single pancreatic beta-cells from ob/ob-mice using the fluorescent indicator fura-2. Raising the glucose concentration from 3 to 20 mM resulted in 25% initial lowering of Ca2+i, followed by 250% rise above the basal level of 49 +/- 3 nM. Tolbutamide (100 microM) was as effective as glucose in increasing Ca2+i, although its action was more rapid and not preceded by any reduction. The results support the concept that stimulated removal of Ca2+ from the cytoplasm is an essential part of the physiological glucose effect on the pancreatic beta-cells." @default.
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- W2024556039 date "1988-01-01" @default.
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- W2024556039 title "Dual effect of glucose on cytoplasmic Ca2+ in single pancreatic β-cells" @default.
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- W2024556039 doi "https://doi.org/10.1016/0006-291x(88)90537-2" @default.
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