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- W2024556472 abstract "Abstract Electric cell-substrate impedance sensing (ECIS) is described for real time monitoring of cell behavior including attachment, motility, and cytotoxicity in a continuous fashion. This emerging technology subjects cells growing on microelectrodes to small ac electric fields. Cells interact differently with various proteins used to precoat the gold electrode. Initial intact extracellular matrix protein binding to cells is often mediated through adhesion receptors in the integrin family with fibronectin as the commonest coating protein. Upon the attachment and spreading of cells, the impedance increases because the cells act as insulating particles to restrict the current flow. An intriguing feature is the fluctuation in the measured impedance, which is always associated with living cells and persists even if the cell layer becomes fully confluent. This behavior is attributed to vertical motions or micromotions of the cells, an indication of cell viability and morphology change. ECIS presents a novel..." @default.
- W2024556472 created "2016-06-24" @default.
- W2024556472 creator A5050123820 @default.
- W2024556472 date "2003-12-31" @default.
- W2024556472 modified "2023-09-23" @default.
- W2024556472 title "An Emerging Impedance Sensor Based on Cell-Protein Interactions: Applications in Cell Biology and Analytical Biochemistry" @default.
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- W2024556472 doi "https://doi.org/10.1081/al-120026565" @default.
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