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• W2024556558 abstract "Nitric oxide (NO) enhances prostacyclin (PGI2) production in agonist-stimulated endothelial cells, while peroxynitrite formed from NO and superoxide anion has been shown to activate cyclooxygenase. Using cultured bovine aortic endothelial cells (BAEC) exposed to arterial levels of laminar shear stress of 25 dynes/cm2, we tested the hypothesis that NO mediated the elevated synthesis of PGI2by shear stressed endothelium. Shear stress caused a large and rapid burst and sustained release of NO and PGI2with the cumulative production at 1 hr enhanced 9.96-fold (n = 4, p < 0.005) and 9.16-fold (n = 3, p < 0.005), respectively, over stationary control production of 0.0257 nmol-NO/cm2-BAEC and 0.0193 ng-PGI2/cm2-BAEC. The NO synthase inhibitors, NG-nitro-l-arginine methyl ester (100 μM, LNAME) and NG-nitro-l-arginine (10 μM, LNA), caused 87.5 and 65% reductions (n = 3, p < 0.02) of cumulative NO release at 1 hr, respectively, and 45 and 55% reductions (n = 3, p = 0.025) of PGI2release, respectively. About half of the elevated production of PGI2in shear stressed cells was due to NO-dependent signaling, indicating that hemodynamic control of these two dilatory molecules is partially coupled." @default.
• W2024556558 created "2016-06-24" @default.
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• W2024556558 date "1997-04-01" @default.
• W2024556558 modified "2023-10-10" @default.
• W2024556558 title "Does Elevated Nitric Oxide Production Enhance the Release of Prostacyclin from Shear Stressed Aortic Endothelial Cells?" @default.
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• W2024556558 doi "https://doi.org/10.1006/bbrc.1997.6548" @default.
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