Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024558229> ?p ?o ?g. }
- W2024558229 endingPage "1325" @default.
- W2024558229 startingPage "1316" @default.
- W2024558229 abstract "The pathogenetic link between ulcerative colitis and sclerosing cholangitis (SC) is unclear. We hypothesized that colitis induces changes in bile composition via inflammation-induced reduction of hepatobiliary transporter gene expression, ultimately resulting in cholestasis and bile duct injury.Alterations in transporter expression and bile secretion in acute dextran sulphate sodium (DSS)-induced colitis were compared with lipopolysaccharide (LPS)-treated mice serving as positive control. Whether chronic DSS-colitis elicits cholangitis in genetically predisposed animals was studied in heterozygous multidrug resistance gene 2 knockout mice (Mdr2(+/-)).LPS but not DSS-colitis changed major hepatobiliary transporters (Ntcp, Bsep, Mrp2-4, Ostalpha/beta, Abcg5/8, Oatp1-4, Mdr1b and Mdr2), enzymes (Cyp3a11 and Cyp7a1), nuclear receptors (RXRalpha, FXR, CAR and PXR) and proinflammatory mediators (tumour necrosis factor alpha and inducible nitric oxide synthase). Formation of toxic bile reflected by an increased bile acid/phospholipid ratio was observed neither in acute nor in chronic colitis, although heterozygous Mdr2(+/-) mice developed mild portal inflammation after chronic colitis.In contrast to LPS, DSS-colitis has a minor impact on hepatobiliary gene expression and bile secretion. Therefore, intestinal inflammation-associated changes of hepatobiliary transporter expression do not play a pathogenetic role in SC." @default.
- W2024558229 created "2016-06-24" @default.
- W2024558229 creator A5007093204 @default.
- W2024558229 creator A5018157538 @default.
- W2024558229 creator A5033307002 @default.
- W2024558229 creator A5036627819 @default.
- W2024558229 creator A5046244856 @default.
- W2024558229 creator A5068631395 @default.
- W2024558229 creator A5075835632 @default.
- W2024558229 creator A5082137277 @default.
- W2024558229 date "2009-10-01" @default.
- W2024558229 modified "2023-10-14" @default.
- W2024558229 title "Impact of experimental colitis on hepatobiliary transporter expression and bile duct injury in mice" @default.
- W2024558229 cites W1717520501 @default.
- W2024558229 cites W1855226200 @default.
- W2024558229 cites W1975064577 @default.
- W2024558229 cites W1982260172 @default.
- W2024558229 cites W1983459355 @default.
- W2024558229 cites W1984345984 @default.
- W2024558229 cites W1991384293 @default.
- W2024558229 cites W2003193619 @default.
- W2024558229 cites W2003517015 @default.
- W2024558229 cites W2019014630 @default.
- W2024558229 cites W2022804237 @default.
- W2024558229 cites W2027043427 @default.
- W2024558229 cites W2028947237 @default.
- W2024558229 cites W2035142444 @default.
- W2024558229 cites W2037316682 @default.
- W2024558229 cites W2039269022 @default.
- W2024558229 cites W2040822561 @default.
- W2024558229 cites W2053915788 @default.
- W2024558229 cites W2055039485 @default.
- W2024558229 cites W2055978469 @default.
- W2024558229 cites W2058793136 @default.
- W2024558229 cites W2062699557 @default.
- W2024558229 cites W2064338792 @default.
- W2024558229 cites W2068600065 @default.
- W2024558229 cites W2071489706 @default.
- W2024558229 cites W2073485174 @default.
- W2024558229 cites W2074964390 @default.
- W2024558229 cites W2076373773 @default.
- W2024558229 cites W2077296435 @default.
- W2024558229 cites W2079491287 @default.
- W2024558229 cites W2080649144 @default.
- W2024558229 cites W2081699679 @default.
- W2024558229 cites W2082168419 @default.
- W2024558229 cites W2087138410 @default.
- W2024558229 cites W2097502628 @default.
- W2024558229 cites W2098628139 @default.
- W2024558229 cites W2101700786 @default.
- W2024558229 cites W2107277218 @default.
- W2024558229 cites W2116601505 @default.
- W2024558229 cites W2128194105 @default.
- W2024558229 cites W2131096427 @default.
- W2024558229 cites W2131238799 @default.
- W2024558229 cites W2158002405 @default.
- W2024558229 cites W2160486989 @default.
- W2024558229 cites W2167543058 @default.
- W2024558229 cites W2339463163 @default.
- W2024558229 cites W4256462507 @default.
- W2024558229 cites W76962327 @default.
- W2024558229 cites W97686115 @default.
- W2024558229 doi "https://doi.org/10.1111/j.1478-3231.2009.02044.x" @default.
- W2024558229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19558576" @default.
- W2024558229 hasPublicationYear "2009" @default.
- W2024558229 type Work @default.
- W2024558229 sameAs 2024558229 @default.
- W2024558229 citedByCount "30" @default.
- W2024558229 countsByYear W20245582292012 @default.
- W2024558229 countsByYear W20245582292013 @default.
- W2024558229 countsByYear W20245582292014 @default.
- W2024558229 countsByYear W20245582292015 @default.
- W2024558229 countsByYear W20245582292016 @default.
- W2024558229 countsByYear W20245582292017 @default.
- W2024558229 countsByYear W20245582292018 @default.
- W2024558229 countsByYear W20245582292019 @default.
- W2024558229 countsByYear W20245582292020 @default.
- W2024558229 countsByYear W20245582292021 @default.
- W2024558229 countsByYear W20245582292022 @default.
- W2024558229 crossrefType "journal-article" @default.
- W2024558229 hasAuthorship W2024558229A5007093204 @default.
- W2024558229 hasAuthorship W2024558229A5018157538 @default.
- W2024558229 hasAuthorship W2024558229A5033307002 @default.
- W2024558229 hasAuthorship W2024558229A5036627819 @default.
- W2024558229 hasAuthorship W2024558229A5046244856 @default.
- W2024558229 hasAuthorship W2024558229A5068631395 @default.
- W2024558229 hasAuthorship W2024558229A5075835632 @default.
- W2024558229 hasAuthorship W2024558229A5082137277 @default.
- W2024558229 hasConcept C104317684 @default.
- W2024558229 hasConcept C126322002 @default.
- W2024558229 hasConcept C134018914 @default.
- W2024558229 hasConcept C149011108 @default.
- W2024558229 hasConcept C164027704 @default.
- W2024558229 hasConcept C2775862500 @default.
- W2024558229 hasConcept C2776637226 @default.
- W2024558229 hasConcept C2776914184 @default.
- W2024558229 hasConcept C2778260677 @default.
- W2024558229 hasConcept C2778593092 @default.