FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024558829> ?p ?o ?g. }

• W2024558829 endingPage "153" @default.
• W2024558829 startingPage "146" @default.
• W2024558829 abstract "The emergence of reduced susceptibility to ciprofloxacin among Salmonella enterica serotype Typhi and serotype Paratyphi A leading to clinical failure of treatment poses a great therapeutic challenge. The mechanism of fluoroquinolone resistance in clinical isolates of S. Typhi and S. Paratyphi A is not very well documented. The present study was carried out with the objective of molecular characterization of reduced quinolone susceptibility amongst the strains of S. Typhi and S. Paratyphi A isolated from the patients with enteric fever during January, 2000, to April, 2003, in a North Indian hospital. A total of 422 culture-positive cases of enteric fever were reported to the hospital during the period of study, of which S. Typhi was isolated from 350 cases and S. Paratyphi A from 72 cases. The antimicrobial susceptibility of these strains was determined by disk diffusion and agar dilution method according to NCCLS guidelines, and E-test method. A total of 140 randomly selected strains, isolated during the years 1993–1999, that were available from the laboratory stocks were also studied to compare with the present strains. To study the quinolone susceptibility, the strains were divided into nalidixic acid sensitive (NAS), nalidixic acid intermediate resistant, (NAI) and nalidixic acid resistant (NAR) on the basis of susceptibility to nalidixic acid. Clinical history was available from 174 patients, of which 93 needed hospitalization due to severe disease. Of these, 82 patients were infected with NAR strains and 22 patients had a documented evidence of clinical failure to ciprofloxacin therapy. The patients infected with NAR strains were younger and had a significantly longer duration of fever (p value < 0.05) than those infected with NAS strains. It was observed that the proportion of NAR strains increased gradually over the years. These strains had a significantly higher range of MIC of ciprofloxacin (0.023–1.0 μg/ml) as compared to the NAS strains (0.002–0.125 μg/ml) (p value < 0.05). The sequencing of quinolone resistancedetermining region (QRDR) of the gyrA gene showed the presence of mutation at either Ser 83 or at Asp 87 in all the NAR and NAI strains. None of the NAS strains had a mutation, suggesting that the gyrA gene mutation is sufficient to confer resistance to nalidixic acid and reduced susceptibility to ciprofloxacin. This mutation, although phenotypically expressed as decreased susceptibility to ciprofloxacin, goes undetected by the disk diffusion method using the present NCCLS guidelines. Hence, it can increase morbidity and mortality due to delay in appropriate antibiotic treatment." @default.
• W2024558829 created "2016-06-24" @default.
• W2024558829 creator A5026175929 @default.
• W2024558829 creator A5051917254 @default.
• W2024558829 creator A5062351807 @default.
• W2024558829 creator A5064834072 @default.
• W2024558829 creator A5084073145 @default.
• W2024558829 creator A5089845154 @default.
• W2024558829 creator A5091293579 @default.
• W2024558829 creator A5091481974 @default.
• W2024558829 date "2004-06-01" @default.
• W2024558829 modified "2023-10-02" @default.
• W2024558829 title "Reduced Susceptibility to Ciprofloxacin and<i>gyrA</i>Gene Mutation in North Indian Strains of<i>Salmonella enterica</i>Serotype Typhi and Serotype Paratyphi A" @default.
• W2024558829 cites W1693659061 @default.
• W2024558829 cites W1813874952 @default.
• W2024558829 cites W1964380041 @default.
• W2024558829 cites W2004782471 @default.
• W2024558829 cites W2008151728 @default.
• W2024558829 cites W2017857173 @default.
• W2024558829 cites W2018382504 @default.
• W2024558829 cites W2028103501 @default.
• W2024558829 cites W2051808700 @default.
• W2024558829 cites W2060029409 @default.
• W2024558829 cites W2071327877 @default.
• W2024558829 cites W2071409678 @default.
• W2024558829 cites W2072024834 @default.
• W2024558829 cites W2078772443 @default.
• W2024558829 cites W2087635930 @default.
• W2024558829 cites W2097382368 @default.
• W2024558829 cites W2102150551 @default.
• W2024558829 cites W2107131874 @default.
• W2024558829 cites W2107880730 @default.
• W2024558829 cites W2108187249 @default.
• W2024558829 cites W2112171260 @default.
• W2024558829 cites W2122273366 @default.
• W2024558829 cites W2134527953 @default.
• W2024558829 cites W2146288504 @default.
• W2024558829 cites W2149374321 @default.
• W2024558829 cites W2154902882 @default.
• W2024558829 cites W2159206412 @default.
• W2024558829 cites W4246341307 @default.
• W2024558829 cites W4250792402 @default.
• W2024558829 doi "https://doi.org/10.1089/1076629041310028" @default.
• W2024558829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15256030" @default.
• W2024558829 hasPublicationYear "2004" @default.
• W2024558829 type Work @default.
• W2024558829 sameAs 2024558829 @default.
• W2024558829 citedByCount "72" @default.
• W2024558829 countsByYear W20245588292012 @default.
• W2024558829 countsByYear W20245588292013 @default.
• W2024558829 countsByYear W20245588292014 @default.
• W2024558829 countsByYear W20245588292015 @default.
• W2024558829 countsByYear W20245588292016 @default.
• W2024558829 countsByYear W20245588292017 @default.
• W2024558829 countsByYear W20245588292018 @default.
• W2024558829 countsByYear W20245588292019 @default.
• W2024558829 countsByYear W20245588292020 @default.
• W2024558829 countsByYear W20245588292021 @default.
• W2024558829 countsByYear W20245588292022 @default.
• W2024558829 countsByYear W20245588292023 @default.
• W2024558829 crossrefType "journal-article" @default.
• W2024558829 hasAuthorship W2024558829A5026175929 @default.
• W2024558829 hasAuthorship W2024558829A5051917254 @default.
• W2024558829 hasAuthorship W2024558829A5062351807 @default.
• W2024558829 hasAuthorship W2024558829A5064834072 @default.
• W2024558829 hasAuthorship W2024558829A5084073145 @default.
• W2024558829 hasAuthorship W2024558829A5089845154 @default.
• W2024558829 hasAuthorship W2024558829A5091293579 @default.
• W2024558829 hasAuthorship W2024558829A5091481974 @default.
• W2024558829 hasConcept C10389963 @default.
• W2024558829 hasConcept C104317684 @default.
• W2024558829 hasConcept C159047783 @default.
• W2024558829 hasConcept C176947019 @default.
• W2024558829 hasConcept C2775876089 @default.
• W2024558829 hasConcept C2778512257 @default.
• W2024558829 hasConcept C2779607309 @default.
• W2024558829 hasConcept C2780493024 @default.
• W2024558829 hasConcept C2781065037 @default.
• W2024558829 hasConcept C2994552716 @default.
• W2024558829 hasConcept C501593827 @default.
• W2024558829 hasConcept C520601542 @default.
• W2024558829 hasConcept C523546767 @default.
• W2024558829 hasConcept C54355233 @default.
• W2024558829 hasConcept C547475151 @default.
• W2024558829 hasConcept C55493867 @default.
• W2024558829 hasConcept C71924100 @default.
• W2024558829 hasConcept C86803240 @default.
• W2024558829 hasConcept C89423630 @default.
• W2024558829 hasConceptScore W2024558829C10389963 @default.
• W2024558829 hasConceptScore W2024558829C104317684 @default.
• W2024558829 hasConceptScore W2024558829C159047783 @default.
• W2024558829 hasConceptScore W2024558829C176947019 @default.
• W2024558829 hasConceptScore W2024558829C2775876089 @default.
• W2024558829 hasConceptScore W2024558829C2778512257 @default.
• W2024558829 hasConceptScore W2024558829C2779607309 @default.
• W2024558829 hasConceptScore W2024558829C2780493024 @default.
• W2024558829 hasConceptScore W2024558829C2781065037 @default.
• W2024558829 hasConceptScore W2024558829C2994552716 @default.

• next