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- W2024558876 abstract "A practical procedure is described for the multigram preparation of disodium disuccinate derivatives of synthetic astaxanthin (Cardax) [from all-trans-(all-E)-3S,3‘S-, meso-(3R,3‘S)-, and 3R,3‘R-dihydroxy-β,β-carotene-4,4‘-dione) in a 1:2:1 statistical mixture of stereoisomers, as well as from the individual component stereoisomers]. Process development eliminated chromatographic separations, controlled geometric isomerization, and improved the overall yield of the two-step process, with significant improvements in both the yield and purity of Cardax. Bulk chromatographic separation of the diastereomeric dicamphanic acid ester of synthetic astaxanthin was performed by modifications of the published procedure to subsequently generate multigram quantities of each stereoisomer of disodium disuccinate of astaxanthin." @default.
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- W2024558876 date "2004-08-12" @default.
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- W2024558876 title "The Efficient Synthesis of Disodium Disuccinate Astaxanthin (Cardax)" @default.
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