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• W2024559161 abstract "The p75 neurotrophin receptor (p75(NTR)) is a known mediator of β-amyloid (Aβ)-induced neurotoxicity implicated in Alzheimer's disease (AD). Here, we demonstrate that death receptor 6 (DR6) binds to p75(NTR) and is a component of the p75(NTR) signaling complex responsible for Aβ-induced cortical neuron death. Cortical neurons isolated from either DR6 or p75(NTR) null mice are resistant to Aβ-induced neurotoxicity. Blocking DR6 function in cortical neurons by anti-DR6 antibodies that block the binding of DR6 to p75(NTR) receptor complex or by a dominant negative DR6 construct lacking the cytoplasmic signaling death domain attenuates Aβ-induced caspase 3 activation and cell death. DR6 expression is upregulated in AD cortex and correlates with elevated neuronal death. Targeting the disruption of the DR6/p75(NTR) complex to prevent Aβ cytotoxicity represents a new approach for the treatment of neurodegenerative disorders such as AD." @default.
• W2024559161 created "2016-06-24" @default.
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• W2024559161 date "2013-04-04" @default.
• W2024559161 modified "2023-10-06" @default.
• W2024559161 title "A DR6/p75NTR complex is responsible for β-amyloid-induced cortical neuron death" @default.
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• W2024559161 doi "https://doi.org/10.1038/cddis.2013.110" @default.
• W2024559161 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3641333" @default.
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