FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024561234> ?p ?o ?g. }

• W2024561234 abstract "Abstract XPD functions in transcription, DNA repair and in cell cycle control. Mutations in human XPD (also known as ERCC2) mainly cause three clinical phenotypes: xeroderma pigmentosum (XP), Cockayne syndrome (XP/CS) and trichothiodystrophy (TTD), and only XP patients have a high predisposition to developing cancer. Hence, we developed a fly model to obtain novel insights into the defects caused by individual hypomorphic alleles identified in human XP-D patients. This model revealed that the mutations that displayed the greatest in vivo UV sensitivity in Drosophila did not correlate with those that led to tumor formation in humans. Immunoprecipitations followed by targeted quantitative MS/MS analysis showed how different xpd mutations affected the formation or stability of different transcription factor IIH (TFIIH) subcomplexes. The XP mutants most clearly linked to high cancer risk, Xpd R683W and R601L, showed a reduced interaction with the core TFIIH and also an abnormal interaction with the Cdk-activating kinase (CAK) complex. Interestingly, these two XP alleles additionally displayed high levels of chromatin loss and free centrosomes during the rapid nuclear division phase of the Drosophila embryo. Finally, the xpd mutations showing defects in the coordination of cell cycle timing during the Drosophila embryonic divisions correlated with those human mutations that cause the neurodevelopmental abnormalities and developmental growth defects observed in XP/CS and TTD patients." @default.
• W2024561234 created "2016-06-24" @default.
• W2024561234 creator A5046054205 @default.
• W2024561234 creator A5046427780 @default.
• W2024561234 creator A5053480067 @default.
• W2024561234 creator A5058978575 @default.
• W2024561234 creator A5069677189 @default.
• W2024561234 creator A5082772840 @default.
• W2024561234 creator A5084461414 @default.
• W2024561234 date "2014-01-01" @default.
• W2024561234 modified "2023-09-24" @default.
• W2024561234 title "A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer" @default.
• W2024561234 cites W1507190685 @default.
• W2024561234 cites W1541218357 @default.
• W2024561234 cites W1555556881 @default.
• W2024561234 cites W1560653563 @default.
• W2024561234 cites W1599133231 @default.
• W2024561234 cites W1600330290 @default.
• W2024561234 cites W1781095925 @default.
• W2024561234 cites W1889593889 @default.
• W2024561234 cites W1966060698 @default.
• W2024561234 cites W1967288647 @default.
• W2024561234 cites W1970011005 @default.
• W2024561234 cites W1970341475 @default.
• W2024561234 cites W1973201073 @default.
• W2024561234 cites W1982918697 @default.
• W2024561234 cites W1991502560 @default.
• W2024561234 cites W1995968975 @default.
• W2024561234 cites W2003848438 @default.
• W2024561234 cites W2004431479 @default.
• W2024561234 cites W2005074055 @default.
• W2024561234 cites W2027481639 @default.
• W2024561234 cites W2030054148 @default.
• W2024561234 cites W2035059002 @default.
• W2024561234 cites W2037435562 @default.
• W2024561234 cites W2038135691 @default.
• W2024561234 cites W2039950901 @default.
• W2024561234 cites W2040289024 @default.
• W2024561234 cites W2052112605 @default.
• W2024561234 cites W2060334131 @default.
• W2024561234 cites W2060834498 @default.
• W2024561234 cites W2071281349 @default.
• W2024561234 cites W2078518665 @default.
• W2024561234 cites W2080266849 @default.
• W2024561234 cites W2080605611 @default.
• W2024561234 cites W2081215759 @default.
• W2024561234 cites W2084369408 @default.
• W2024561234 cites W2086639667 @default.
• W2024561234 cites W2090817340 @default.
• W2024561234 cites W2093467153 @default.
• W2024561234 cites W2094608143 @default.
• W2024561234 cites W2095033674 @default.
• W2024561234 cites W2095761412 @default.
• W2024561234 cites W2109734925 @default.
• W2024561234 cites W2114382972 @default.
• W2024561234 cites W2117249902 @default.
• W2024561234 cites W2121759775 @default.
• W2024561234 cites W2124757429 @default.
• W2024561234 cites W2125757091 @default.
• W2024561234 cites W2127678435 @default.
• W2024561234 cites W2127857475 @default.
• W2024561234 cites W2128774980 @default.
• W2024561234 cites W2140835818 @default.
• W2024561234 cites W2145587814 @default.
• W2024561234 cites W2150270763 @default.
• W2024561234 cites W2153823300 @default.
• W2024561234 cites W2157353280 @default.
• W2024561234 cites W2158045853 @default.
• W2024561234 cites W2164670061 @default.
• W2024561234 cites W2167956098 @default.
• W2024561234 cites W2168320283 @default.
• W2024561234 cites W2169295539 @default.
• W2024561234 cites W2322371889 @default.
• W2024561234 cites W4244842284 @default.
• W2024561234 doi "https://doi.org/10.1242/dmm.016907" @default.
• W2024561234 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4283652" @default.
• W2024561234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25431422" @default.
• W2024561234 hasPublicationYear "2014" @default.
• W2024561234 type Work @default.
• W2024561234 sameAs 2024561234 @default.
• W2024561234 citedByCount "6" @default.
• W2024561234 countsByYear W20245612342015 @default.
• W2024561234 countsByYear W20245612342016 @default.
• W2024561234 countsByYear W20245612342017 @default.
• W2024561234 countsByYear W20245612342019 @default.
• W2024561234 countsByYear W20245612342020 @default.
• W2024561234 crossrefType "journal-article" @default.
• W2024561234 hasAuthorship W2024561234A5046054205 @default.
• W2024561234 hasAuthorship W2024561234A5046427780 @default.
• W2024561234 hasAuthorship W2024561234A5053480067 @default.
• W2024561234 hasAuthorship W2024561234A5058978575 @default.
• W2024561234 hasAuthorship W2024561234A5069677189 @default.
• W2024561234 hasAuthorship W2024561234A5082772840 @default.
• W2024561234 hasAuthorship W2024561234A5084461414 @default.
• W2024561234 hasBestOaLocation W20245612341 @default.
• W2024561234 hasConcept C104451858 @default.
• W2024561234 hasConcept C134935766 @default.
• W2024561234 hasConcept C2778378917 @default.
• W2024561234 hasConcept C2779371275 @default.
• W2024561234 hasConcept C502942594 @default.

• next