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• W2024561549 endingPage "2245" @default.
• W2024561549 startingPage "2233" @default.
• W2024561549 abstract "In addition to its central effects on appetite regulation, leptin has been implicated in immune function and inflammation. Previous data suggested that leptin acts as an inflammatory signal within the brain, as exogenously administered leptin induced fever, a typical brain-regulated inflammatory response. The present study aimed to delineate the inflammatory actions and cellular targets of leptin in the brain by examining its effects on the expression of interleukin (IL)-1beta and cyclooxygenase (COX)-2, two important inflammatory components of the fever response. Intracerebroventricular injection of leptin (5 microg/rat) induced IL-1beta and COX-2 mRNA and protein in the hypothalamus between 1 and 3 h after treatment as determined by reverse transcription-polymerase chain reaction and immunohistochemistry. Coinjection of IL-1 receptor antagonist (100 microg/rat, intracerebroventricular) attenuated leptin-induced COX-2, whereas IL-1 receptor antagonist had no effect on endogenous IL-1beta levels, suggesting that leptin induces COX-2 via, at least partly, IL-1beta action. IL-1beta protein expression was induced in macrophages in the meningis and perivascular space after leptin treatment, whereas COX-2 induction was observed in endothelial cells, indicating the roles for these non-neuronal cells in mediating inflammatory actions of leptin. In addition, neutralization of endogenous circulating leptin with anti-leptin antiserum attenuated intraperitoneal lipopolysaccharide (100 microg/kg)-induced brain IL-1beta and COX-2 upregulation, suggesting that leptin indeed acts as an inflammatory signal to the brain during systemic inflammation. These findings are in contrast to the effects of leptin on appetite regulation where it is believed to act primarily on neurons, thus presenting a distinct anatomical basis for the inflammatory and appetite regulatory actions of leptin in the brain." @default.
• W2024561549 created "2016-06-24" @default.
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• W2024561549 creator A5051661893 @default.
• W2024561549 creator A5051743483 @default.
• W2024561549 date "2006-10-01" @default.
• W2024561549 modified "2023-10-10" @default.
• W2024561549 title "Leptin induces cyclooxygenase-2 via an interaction with interleukin-1β in the rat brain" @default.
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• W2024561549 cites W1964089588 @default.
• W2024561549 cites W1966639644 @default.
• W2024561549 cites W1967760510 @default.
• W2024561549 cites W1980153282 @default.
• W2024561549 cites W1984553097 @default.
• W2024561549 cites W1991810873 @default.
• W2024561549 cites W1993203791 @default.
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• W2024561549 cites W2021912070 @default.
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• W2024561549 cites W2055928093 @default.
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• W2024561549 cites W2150451033 @default.
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• W2024561549 doi "https://doi.org/10.1111/j.1460-9568.2006.05105.x" @default.
• W2024561549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17074047" @default.
• W2024561549 hasPublicationYear "2006" @default.
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