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• W2024561575 abstract "Persistent activation of GABA A receptors by extracellular GABA (tonic inhibition) plays a critical role in signal processing and network excitability in the brain. In hippocampal principal cells, tonic inhibition has been reported to be mediated by α5-subunit-containing GABA A receptors (α5GABA A Rs). Pharmacological or genetic disruption of these receptors improves cognitive performance, suggesting that tonic inhibition has an adverse effect on information processing. Here, we show that α5GABA A Rs contribute to tonic currents in pyramidal cells only when ambient GABA concentrations increase (as may occur during increased brain activity). At low ambient GABA concentrations, activation of δ-subunit-containing GABA A receptors predominates. In epileptic tissue, α5GABA A Rs are downregulated and no longer contribute to tonic currents under conditions of raised extracellular GABA concentrations. Under these conditions, however, the tonic current is greater in pyramidal cells from epileptic tissue than in pyramidal cells from nonepileptic tissue, implying substitution of α5GABA A Rs by other GABA A receptor subtypes. These results reveal multiple components of tonic GABA A receptor-mediated conductance that are activated by low GABA concentrations. The relative contribution of these components changes after the induction of epilepsy, implying an adaptive plasticity of the tonic current in the presence of spontaneous seizures." @default.
• W2024561575 created "2016-06-24" @default.
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• W2024561575 date "2005-10-26" @default.
• W2024561575 modified "2023-10-11" @default.
• W2024561575 title "Multiple and Plastic Receptors Mediate Tonic GABA_AReceptor Currents in the Hippocampus" @default.
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• W2024561575 doi "https://doi.org/10.1523/jneurosci.2520-05.2005" @default.
• W2024561575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6725560" @default.
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