FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024562235> ?p ?o ?g. }

• W2024562235 endingPage "703" @default.
• W2024562235 startingPage "696" @default.
• W2024562235 abstract "The pleiotropic cytokine interleukin-1β (IL-1β) can promote physiological cell migration, as well as cancer cell invasion and metastasis. Its role in human trophoblast invasion, however, has not been satisfactorily answered since direct, indirect as well as no effects on trophoblast motility have been published. Therefore, the role of IL-1β has been re-evaluated by exclusively using human primary trophoblast model systems. Immunofluorescence of first trimester placentae indicated IL-1 receptor 1 (IL-1R1) protein expression in first trimester villous cytotrophoblasts (vCTB) and extravillous trophoblasts (EVT). The latter expressed higher mRNA levels of the receptor as shown by comparative gene chip data of vCTB and EVT. Similarly, Western blot analyses and immunofluorescence revealed a time- and differentiation-dependent increase of IL-1R1 in primary EVT seeded on fibronectin. IL-1β dose-dependently elevated migration of isolated first trimester EVT through fibronectin-coated transwells, which was inhibited in the presence of IL-1R antagonist (IL-1Ra), whereas proliferation of these cells was not affected. Similarly, the interleukin did not alter proliferation of vCTB and cell column trophoblasts in floating villi of early pregnancy, but promoted migration in villous explant cultures seeded on collagen I. Western blot analyses of supernatants of primary EVT and first trimester villous explant cultures revealed IL-1β induced secretion of urokinase plasminogen activator (uPA), plasminogen activator inhibitor (PAI)-1 and PAI-2, which was diminished upon combined IL-1β/IL-1Ra treatment. In conclusion, these data suggest that IL-1β directly promotes trophoblast motility of first trimester EVT involving the uPA/PAI system." @default.
• W2024562235 created "2016-06-24" @default.
• W2024562235 creator A5004186307 @default.
• W2024562235 creator A5012777587 @default.
• W2024562235 creator A5019734869 @default.
• W2024562235 creator A5020628846 @default.
• W2024562235 creator A5061334896 @default.
• W2024562235 creator A5073970281 @default.
• W2024562235 creator A5090820768 @default.
• W2024562235 date "2012-09-01" @default.
• W2024562235 modified "2023-09-24" @default.
• W2024562235 title "The role of interleukin-1β in human trophoblast motility" @default.
• W2024562235 cites W1498159349 @default.
• W2024562235 cites W1502651723 @default.
• W2024562235 cites W1509926487 @default.
• W2024562235 cites W1535865314 @default.
• W2024562235 cites W1558546727 @default.
• W2024562235 cites W1911418737 @default.
• W2024562235 cites W193754658 @default.
• W2024562235 cites W1965375124 @default.
• W2024562235 cites W1971252244 @default.
• W2024562235 cites W1971528193 @default.
• W2024562235 cites W1975195151 @default.
• W2024562235 cites W1983895762 @default.
• W2024562235 cites W1987758321 @default.
• W2024562235 cites W1999090873 @default.
• W2024562235 cites W2001293389 @default.
• W2024562235 cites W2011781624 @default.
• W2024562235 cites W2014791049 @default.
• W2024562235 cites W2021970761 @default.
• W2024562235 cites W2023144895 @default.
• W2024562235 cites W2036859091 @default.
• W2024562235 cites W2044620515 @default.
• W2024562235 cites W2044692553 @default.
• W2024562235 cites W2052472879 @default.
• W2024562235 cites W2058018180 @default.
• W2024562235 cites W2058177024 @default.
• W2024562235 cites W2064641688 @default.
• W2024562235 cites W2079853478 @default.
• W2024562235 cites W2080637499 @default.
• W2024562235 cites W2081734818 @default.
• W2024562235 cites W2082700691 @default.
• W2024562235 cites W2083444590 @default.
• W2024562235 cites W2094382350 @default.
• W2024562235 cites W2104579843 @default.
• W2024562235 cites W2108209424 @default.
• W2024562235 cites W2120941190 @default.
• W2024562235 cites W2137262465 @default.
• W2024562235 cites W2148343654 @default.
• W2024562235 cites W2148950320 @default.
• W2024562235 cites W2150107812 @default.
• W2024562235 cites W2151780324 @default.
• W2024562235 cites W2153993787 @default.
• W2024562235 cites W2155925117 @default.
• W2024562235 cites W2167383223 @default.
• W2024562235 cites W2168063892 @default.
• W2024562235 cites W2171391855 @default.
• W2024562235 cites W2408554838 @default.
• W2024562235 cites W4243140277 @default.
• W2024562235 cites W4245575456 @default.
• W2024562235 doi "https://doi.org/10.1016/j.placenta.2012.05.008" @default.
• W2024562235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3432868" @default.
• W2024562235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22710193" @default.
• W2024562235 hasPublicationYear "2012" @default.
• W2024562235 type Work @default.
• W2024562235 sameAs 2024562235 @default.
• W2024562235 citedByCount "67" @default.
• W2024562235 countsByYear W20245622352013 @default.
• W2024562235 countsByYear W20245622352014 @default.
• W2024562235 countsByYear W20245622352015 @default.
• W2024562235 countsByYear W20245622352016 @default.
• W2024562235 countsByYear W20245622352017 @default.
• W2024562235 countsByYear W20245622352018 @default.
• W2024562235 countsByYear W20245622352019 @default.
• W2024562235 countsByYear W20245622352020 @default.
• W2024562235 countsByYear W20245622352021 @default.
• W2024562235 countsByYear W20245622352022 @default.
• W2024562235 countsByYear W20245622352023 @default.
• W2024562235 crossrefType "journal-article" @default.
• W2024562235 hasAuthorship W2024562235A5004186307 @default.
• W2024562235 hasAuthorship W2024562235A5012777587 @default.
• W2024562235 hasAuthorship W2024562235A5019734869 @default.
• W2024562235 hasAuthorship W2024562235A5020628846 @default.
• W2024562235 hasAuthorship W2024562235A5061334896 @default.
• W2024562235 hasAuthorship W2024562235A5073970281 @default.
• W2024562235 hasAuthorship W2024562235A5090820768 @default.
• W2024562235 hasBestOaLocation W20245622351 @default.
• W2024562235 hasConcept C104317684 @default.
• W2024562235 hasConcept C134018914 @default.
• W2024562235 hasConcept C16685009 @default.
• W2024562235 hasConcept C170493617 @default.
• W2024562235 hasConcept C172680121 @default.
• W2024562235 hasConcept C189165786 @default.
• W2024562235 hasConcept C2776415932 @default.
• W2024562235 hasConcept C2776953305 @default.
• W2024562235 hasConcept C2777495146 @default.
• W2024562235 hasConcept C2779234561 @default.
• W2024562235 hasConcept C2779679481 @default.

• next