Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024562322> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2024562322 endingPage "1191" @default.
- W2024562322 startingPage "1191" @default.
- W2024562322 abstract "To determine whether rabbit cartilage can be tissue engineered using a polyglycolic acid (PGA) construct composed of PGA mesh, autologous chondrocytes, and alginate covalently linked with the cell adhesion sequence arginine-glycine-aspartic acid (RGD), and to investigate the feasibility of reconstructing tracheal defects using the PGA construct in conjunction with a bioabsorbable intratracheal stent.Nineteen New Zealand White rabbits were used. Nine rabbits underwent subcutaneous implantation of 3 different PGA construct combinations: (1) PGA, autologous chondrocytes, and RGD-modified alginate; (2) PGA, autologous chondrocytes, and unmodified alginate; and (3) PGA and RGD-modified alginate. The remaining 10 animals underwent anterior tracheal reconstruction using fascia lata grafts and the complete PGA construct (PGA, autologous chondrocytes, and RGD-modified alginate). At the time of tracheal reconstruction, a poly-l-lactic acid intratracheal stent was placed in 5 of these latter animals. Rates of tracheal stenosis and mortality were compared with those of historical control animals. Histologic analysis was performed on the PGA constructs.In the subcutaneous implants, the PGA constructs made with chondrocytes (with and without RGD) demonstrated mature cartilage formation in 7 (78%) of the 9 animals. No cartilage was seen in PGA constructs made without chondrocytes. Two of the 10 animals that underwent tracheal reconstruction with the complete PGA construct survived to 20 weeks and demonstrated patent airways, 1 with a stent and 1 without a stent (80% overall mortality). Histologic analysis showed mature cartilage formation at the tracheal reconstruction site. Historical control animals that underwent reconstruction with fascia lata alone demonstrated the lowest overall mortality.Cartilage can be tissue engineered in rabbits using PGA mesh embedded with alginate-encapsulated autologous chondrocytes. It is also possible to reconstruct tracheal defects with this method of cartilage engineering, although the mortality rate in this study is high." @default.
- W2024562322 created "2016-06-24" @default.
- W2024562322 creator A5001106348 @default.
- W2024562322 creator A5001336137 @default.
- W2024562322 creator A5004956606 @default.
- W2024562322 creator A5010591765 @default.
- W2024562322 creator A5028180767 @default.
- W2024562322 creator A5063000923 @default.
- W2024562322 creator A5078723616 @default.
- W2024562322 date "2004-10-01" @default.
- W2024562322 modified "2023-10-18" @default.
- W2024562322 title "Tracheal Reconstruction Using Tissue-Engineered Cartilage" @default.
- W2024562322 cites W1970576706 @default.
- W2024562322 cites W1992573680 @default.
- W2024562322 cites W1996709540 @default.
- W2024562322 cites W2012868907 @default.
- W2024562322 cites W2015208358 @default.
- W2024562322 cites W2032440635 @default.
- W2024562322 cites W2035778689 @default.
- W2024562322 cites W2045274824 @default.
- W2024562322 cites W2083302374 @default.
- W2024562322 cites W2100453415 @default.
- W2024562322 cites W2129844699 @default.
- W2024562322 cites W2151776485 @default.
- W2024562322 cites W2170279469 @default.
- W2024562322 cites W2411936794 @default.
- W2024562322 cites W2418931595 @default.
- W2024562322 cites W35496378 @default.
- W2024562322 cites W936306301 @default.
- W2024562322 doi "https://doi.org/10.1001/archotol.130.10.1191" @default.
- W2024562322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15492167" @default.
- W2024562322 hasPublicationYear "2004" @default.
- W2024562322 type Work @default.
- W2024562322 sameAs 2024562322 @default.
- W2024562322 citedByCount "69" @default.
- W2024562322 countsByYear W20245623222012 @default.
- W2024562322 countsByYear W20245623222013 @default.
- W2024562322 countsByYear W20245623222014 @default.
- W2024562322 countsByYear W20245623222015 @default.
- W2024562322 countsByYear W20245623222016 @default.
- W2024562322 countsByYear W20245623222017 @default.
- W2024562322 countsByYear W20245623222018 @default.
- W2024562322 countsByYear W20245623222019 @default.
- W2024562322 countsByYear W20245623222020 @default.
- W2024562322 countsByYear W20245623222021 @default.
- W2024562322 countsByYear W20245623222022 @default.
- W2024562322 countsByYear W20245623222023 @default.
- W2024562322 crossrefType "journal-article" @default.
- W2024562322 hasAuthorship W2024562322A5001106348 @default.
- W2024562322 hasAuthorship W2024562322A5001336137 @default.
- W2024562322 hasAuthorship W2024562322A5004956606 @default.
- W2024562322 hasAuthorship W2024562322A5010591765 @default.
- W2024562322 hasAuthorship W2024562322A5028180767 @default.
- W2024562322 hasAuthorship W2024562322A5063000923 @default.
- W2024562322 hasAuthorship W2024562322A5078723616 @default.
- W2024562322 hasConcept C105702510 @default.
- W2024562322 hasConcept C136229726 @default.
- W2024562322 hasConcept C141071460 @default.
- W2024562322 hasConcept C185592680 @default.
- W2024562322 hasConcept C2778583881 @default.
- W2024562322 hasConcept C2780550940 @default.
- W2024562322 hasConcept C2780886866 @default.
- W2024562322 hasConcept C2781223772 @default.
- W2024562322 hasConcept C49892992 @default.
- W2024562322 hasConcept C71924100 @default.
- W2024562322 hasConceptScore W2024562322C105702510 @default.
- W2024562322 hasConceptScore W2024562322C136229726 @default.
- W2024562322 hasConceptScore W2024562322C141071460 @default.
- W2024562322 hasConceptScore W2024562322C185592680 @default.
- W2024562322 hasConceptScore W2024562322C2778583881 @default.
- W2024562322 hasConceptScore W2024562322C2780550940 @default.
- W2024562322 hasConceptScore W2024562322C2780886866 @default.
- W2024562322 hasConceptScore W2024562322C2781223772 @default.
- W2024562322 hasConceptScore W2024562322C49892992 @default.
- W2024562322 hasConceptScore W2024562322C71924100 @default.
- W2024562322 hasIssue "10" @default.
- W2024562322 hasLocation W20245623221 @default.
- W2024562322 hasLocation W20245623222 @default.
- W2024562322 hasOpenAccess W2024562322 @default.
- W2024562322 hasPrimaryLocation W20245623221 @default.
- W2024562322 hasRelatedWork W1995566268 @default.
- W2024562322 hasRelatedWork W2038522881 @default.
- W2024562322 hasRelatedWork W2319609803 @default.
- W2024562322 hasRelatedWork W2760469928 @default.
- W2024562322 hasRelatedWork W2792623789 @default.
- W2024562322 hasRelatedWork W2792993462 @default.
- W2024562322 hasRelatedWork W2990262330 @default.
- W2024562322 hasRelatedWork W3127292884 @default.
- W2024562322 hasRelatedWork W40291515 @default.
- W2024562322 hasRelatedWork W604899904 @default.
- W2024562322 hasVolume "130" @default.
- W2024562322 isParatext "false" @default.
- W2024562322 isRetracted "false" @default.
- W2024562322 magId "2024562322" @default.
- W2024562322 workType "article" @default.