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• W2024562705 abstract "Hematopoietic stem cells (HSC) are defined by self-renewal and multilineage differentiation potentials. In order to uncover the genetic program of HSC, we utilized high-density arrays to compare gene expression in highly purified mouse HSC and their mature progeny. One molecule specifically expressed in immature cells is CD27, a member of the TNF receptor family previously shown to play roles in lymphoid proliferation, differentiation, and apoptosis. We show here that the CD27 protein is expressed by about 90% of cells in a purified HSC population. Interestingly, the CD27pos cells are enriched for cells with short-term hematopoietic activities (colony forming potential in vivo and in vitro), while the minority CD27neg population is more effective in clonal long-term transplantation." @default.
• W2024562705 created "2016-06-24" @default.
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• W2024562705 date "2000-02-01" @default.
• W2024562705 modified "2023-09-26" @default.
• W2024562705 title "Expression of CD27 on Murine Hematopoietic Stem and Progenitor Cells" @default.
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• W2024562705 doi "https://doi.org/10.1016/s1074-7613(00)80172-7" @default.
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