FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024563459> ?p ?o ?g. }

• W2024563459 endingPage "158" @default.
• W2024563459 startingPage "149" @default.
• W2024563459 abstract "AS101 (ammonium trichloro(dioxyethylene-0,0')tellurate) is a new synthetic compound previously described by us as having immunomodulating properties and minimal toxicity. Phase II clinical trials are currently in progress with AS101 on cancer patients. AS101 has been recently found to have both radioprotective and chemoprotective effects on hemopoiesis of irradiated mice or mice treated with various chemotherapeutic drugs. The present research was designed to study the in vivo induction of liver acute phase proteins secretion in mice or patients treated with AS101. Induction of these proteins, some of which have the capacity to scavenge free radicals, may contribute to radioprotection. We present evidence that treatment with the immunomodulator AS101 increases production of a variety of acute phase proteins. We demonstrate a significant elevation of serum amyloid A (SAA) in sera of treated mice, as well as an increase in SAA, factor B and ceruloplasmin in sera of patients treated with AS101. The same AS101 treatment was shown to decrease the amount of the negative acute phase protein, albumin. In addition we show that IL-1, IL-6 and TNF-alpha are important mediators of changes in SAA concentrations induced by AS101. Abrogation of SAA production in AS101 treated mice by any one of the anti IL-1R, IL-6R or TNF-alpha antibodies indicates that at least in mice, SAA production is not controlled by a single extracellular signal, but rather it is regulated, at the least, by all three cytokines in various combinations. A better understanding of the mechanism by which AS101 confers radioprotection will enable us to use it more effectively in the restoration of hemopoiesis in patients following radiation or suffering from overdose or accidental radiation." @default.
• W2024563459 created "2016-06-24" @default.
• W2024563459 creator A5003790642 @default.
• W2024563459 creator A5017351947 @default.
• W2024563459 creator A5063744115 @default.
• W2024563459 creator A5073323129 @default.
• W2024563459 date "1995-03-01" @default.
• W2024563459 modified "2023-09-25" @default.
• W2024563459 title "Induction of acute phase proteins in mice and humans by treatment with AS101, an immunomodulator with radioprotective properties" @default.
• W2024563459 cites W1482979909 @default.
• W2024563459 cites W1566351800 @default.
• W2024563459 cites W1568339295 @default.
• W2024563459 cites W1580665972 @default.
• W2024563459 cites W1911326922 @default.
• W2024563459 cites W1965952579 @default.
• W2024563459 cites W1970197409 @default.
• W2024563459 cites W1975438992 @default.
• W2024563459 cites W2002255522 @default.
• W2024563459 cites W2004626037 @default.
• W2024563459 cites W2013503792 @default.
• W2024563459 cites W2015293426 @default.
• W2024563459 cites W2024365580 @default.
• W2024563459 cites W2051613486 @default.
• W2024563459 cites W2075840772 @default.
• W2024563459 cites W2081482521 @default.
• W2024563459 cites W2081518650 @default.
• W2024563459 cites W2104658269 @default.
• W2024563459 cites W2125297115 @default.
• W2024563459 cites W2333758768 @default.
• W2024563459 cites W4232711777 @default.
• W2024563459 doi "https://doi.org/10.1016/0162-3109(94)00054-j" @default.
• W2024563459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7539780" @default.
• W2024563459 hasPublicationYear "1995" @default.
• W2024563459 type Work @default.
• W2024563459 sameAs 2024563459 @default.
• W2024563459 citedByCount "8" @default.
• W2024563459 crossrefType "journal-article" @default.
• W2024563459 hasAuthorship W2024563459A5003790642 @default.
• W2024563459 hasAuthorship W2024563459A5017351947 @default.
• W2024563459 hasAuthorship W2024563459A5063744115 @default.
• W2024563459 hasAuthorship W2024563459A5073323129 @default.
• W2024563459 hasConcept C116263406 @default.
• W2024563459 hasConcept C126322002 @default.
• W2024563459 hasConcept C150903083 @default.
• W2024563459 hasConcept C17991360 @default.
• W2024563459 hasConcept C203014093 @default.
• W2024563459 hasConcept C207001950 @default.
• W2024563459 hasConcept C2776125364 @default.
• W2024563459 hasConcept C2776914184 @default.
• W2024563459 hasConcept C28452662 @default.
• W2024563459 hasConcept C29730261 @default.
• W2024563459 hasConcept C57194454 @default.
• W2024563459 hasConcept C71924100 @default.
• W2024563459 hasConcept C86803240 @default.
• W2024563459 hasConcept C98274493 @default.
• W2024563459 hasConceptScore W2024563459C116263406 @default.
• W2024563459 hasConceptScore W2024563459C126322002 @default.
• W2024563459 hasConceptScore W2024563459C150903083 @default.
• W2024563459 hasConceptScore W2024563459C17991360 @default.
• W2024563459 hasConceptScore W2024563459C203014093 @default.
• W2024563459 hasConceptScore W2024563459C207001950 @default.
• W2024563459 hasConceptScore W2024563459C2776125364 @default.
• W2024563459 hasConceptScore W2024563459C2776914184 @default.
• W2024563459 hasConceptScore W2024563459C28452662 @default.
• W2024563459 hasConceptScore W2024563459C29730261 @default.
• W2024563459 hasConceptScore W2024563459C57194454 @default.
• W2024563459 hasConceptScore W2024563459C71924100 @default.
• W2024563459 hasConceptScore W2024563459C86803240 @default.
• W2024563459 hasConceptScore W2024563459C98274493 @default.
• W2024563459 hasIssue "2" @default.
• W2024563459 hasLocation W20245634591 @default.
• W2024563459 hasLocation W20245634592 @default.
• W2024563459 hasOpenAccess W2024563459 @default.
• W2024563459 hasPrimaryLocation W20245634591 @default.
• W2024563459 hasRelatedWork W108799148 @default.
• W2024563459 hasRelatedWork W1554794074 @default.
• W2024563459 hasRelatedWork W1966387589 @default.
• W2024563459 hasRelatedWork W2037095201 @default.
• W2024563459 hasRelatedWork W2079763637 @default.
• W2024563459 hasRelatedWork W2081217596 @default.
• W2024563459 hasRelatedWork W2521024263 @default.
• W2024563459 hasRelatedWork W3021018257 @default.
• W2024563459 hasRelatedWork W3027423815 @default.
• W2024563459 hasRelatedWork W4293406981 @default.
• W2024563459 hasVolume "29" @default.
• W2024563459 isParatext "false" @default.
• W2024563459 isRetracted "false" @default.
• W2024563459 magId "2024563459" @default.
• W2024563459 workType "article" @default.