Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024570136> ?p ?o ?g. }
- W2024570136 endingPage "386" @default.
- W2024570136 startingPage "378" @default.
- W2024570136 abstract "Toll-like receptors (TLRs) are master regulators of innate immunity and play an integral role in the activation of inflammatory response during infections. In addition, TLRs influence the body's response to numerous forms of injury. Recent data have shown that TLRs play a modulating role in ischemic brain damage after stroke. Interestingly, their stimulation before ischemia induces a tolerant state that is neuroprotective. This phenomenon, referred to as TLR preconditioning, is the result of the reprogramming of TLR response to ischemic injury. This review addresses the role of TLRs in brain ischemia and the activation of endogenous neuroprotective pathways in the setting of preconditioning. We highlight the protective role of interferon-related response and the potential site of action for TLR preconditioning involving the blood-brain barrier. Pharmacologic modulation of TLR activation to promote protection against stroke is a promising approach for the development of prophylactic and immediate therapies targeting ischemic brain injury." @default.
- W2024570136 created "2016-06-24" @default.
- W2024570136 creator A5020613201 @default.
- W2024570136 creator A5049562137 @default.
- W2024570136 creator A5085764362 @default.
- W2024570136 date "2014-05-01" @default.
- W2024570136 modified "2023-10-04" @default.
- W2024570136 title "Toll-Like Receptors and Ischemic Brain Injury" @default.
- W2024570136 cites W1503511302 @default.
- W2024570136 cites W1964503828 @default.
- W2024570136 cites W1969179618 @default.
- W2024570136 cites W1970009717 @default.
- W2024570136 cites W1970291282 @default.
- W2024570136 cites W1971159096 @default.
- W2024570136 cites W1972179333 @default.
- W2024570136 cites W1975240939 @default.
- W2024570136 cites W1976010325 @default.
- W2024570136 cites W1977935404 @default.
- W2024570136 cites W1978903658 @default.
- W2024570136 cites W1983419107 @default.
- W2024570136 cites W1985419968 @default.
- W2024570136 cites W1985808298 @default.
- W2024570136 cites W1991355498 @default.
- W2024570136 cites W1993051305 @default.
- W2024570136 cites W1995744610 @default.
- W2024570136 cites W2004149652 @default.
- W2024570136 cites W2004465286 @default.
- W2024570136 cites W2004622194 @default.
- W2024570136 cites W2004892078 @default.
- W2024570136 cites W2007317274 @default.
- W2024570136 cites W2009887080 @default.
- W2024570136 cites W2010980945 @default.
- W2024570136 cites W2012154384 @default.
- W2024570136 cites W2017505028 @default.
- W2024570136 cites W2021008015 @default.
- W2024570136 cites W2023456725 @default.
- W2024570136 cites W2029784552 @default.
- W2024570136 cites W2031106660 @default.
- W2024570136 cites W2031236369 @default.
- W2024570136 cites W2042086263 @default.
- W2024570136 cites W2042368174 @default.
- W2024570136 cites W2045098547 @default.
- W2024570136 cites W2047218153 @default.
- W2024570136 cites W2047775628 @default.
- W2024570136 cites W2048455147 @default.
- W2024570136 cites W2050798868 @default.
- W2024570136 cites W2054766445 @default.
- W2024570136 cites W2056190116 @default.
- W2024570136 cites W2057062377 @default.
- W2024570136 cites W2059289660 @default.
- W2024570136 cites W2059453959 @default.
- W2024570136 cites W2062993799 @default.
- W2024570136 cites W2063574886 @default.
- W2024570136 cites W2065549997 @default.
- W2024570136 cites W2070862295 @default.
- W2024570136 cites W2078150553 @default.
- W2024570136 cites W2079022347 @default.
- W2024570136 cites W2080271028 @default.
- W2024570136 cites W2080424756 @default.
- W2024570136 cites W2089159998 @default.
- W2024570136 cites W2090411942 @default.
- W2024570136 cites W2107797288 @default.
- W2024570136 cites W2108388278 @default.
- W2024570136 cites W2109491705 @default.
- W2024570136 cites W2112476462 @default.
- W2024570136 cites W2114855685 @default.
- W2024570136 cites W2118200665 @default.
- W2024570136 cites W2132594700 @default.
- W2024570136 cites W2137812201 @default.
- W2024570136 cites W2138028824 @default.
- W2024570136 cites W2144675149 @default.
- W2024570136 cites W2144806891 @default.
- W2024570136 cites W2147259348 @default.
- W2024570136 cites W2149240296 @default.
- W2024570136 cites W2160243792 @default.
- W2024570136 cites W2166660871 @default.
- W2024570136 cites W4292329040 @default.
- W2024570136 doi "https://doi.org/10.1097/nen.0000000000000068" @default.
- W2024570136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4115675" @default.
- W2024570136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24709682" @default.
- W2024570136 hasPublicationYear "2014" @default.
- W2024570136 type Work @default.
- W2024570136 sameAs 2024570136 @default.
- W2024570136 citedByCount "92" @default.
- W2024570136 countsByYear W20245701362014 @default.
- W2024570136 countsByYear W20245701362015 @default.
- W2024570136 countsByYear W20245701362016 @default.
- W2024570136 countsByYear W20245701362017 @default.
- W2024570136 countsByYear W20245701362018 @default.
- W2024570136 countsByYear W20245701362019 @default.
- W2024570136 countsByYear W20245701362020 @default.
- W2024570136 countsByYear W20245701362021 @default.
- W2024570136 countsByYear W20245701362022 @default.
- W2024570136 countsByYear W20245701362023 @default.
- W2024570136 crossrefType "journal-article" @default.
- W2024570136 hasAuthorship W2024570136A5020613201 @default.
- W2024570136 hasAuthorship W2024570136A5049562137 @default.
- W2024570136 hasAuthorship W2024570136A5085764362 @default.