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- W2024572372 abstract "Serotonin N-acetyltransferase, an enzyme of the pineal gland, converts serotonin to N-acetylserotonin. The activity of this enzyme is induced by norepinephrine in the evening to reach high levels during the dark phase. Delta-sleep-inducing peptide, a humoral sleep factor, also seems to affect circadian rhythms. Intravenous injection of this peptide or either of two of its analogs in the evening significantly reduced the increase of N-acetyltransferase 4 h later. The dose-response relationship of the peptides showed an inverted U-shaped pattern with the active dose about 30 nmol/kg. The effect appears to be dependent on the time of day of administration, as injections in the morning did not change the enzymatic activity. These findings indicate that delta-sleep-inducing peptide (and two of its analogs) can affect enzymatic activities and that these influences probably vary throughout a time period of 24 h." @default.
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- W2024572372 date "1985-02-01" @default.
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- W2024572372 title "Delta-Sleep-Inducing Peptide and Two of Its Analogs Reduce Nocturnal Increase of N-Acetyltransferase Activity in Rat Pineal Gland" @default.
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- W2024572372 doi "https://doi.org/10.1111/j.1471-4159.1985.tb05458.x" @default.
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