FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024573923> ?p ?o ?g. }

• W2024573923 abstract "LH secretion is maximal during the night in pubertal boys, and testosterone (T) administration blunts this nocturnal rise of LH. We have previously shown that in pubertal boys, the acute negative feedback effects of T infusion on LH secretion during the daytime cannot be reversed by opioid receptor blockade. To determine whether the nocturnal secretion of LH in early puberty is regulated by endogenous opioid pathways, we determined whether naloxone during the night affected LH secretion or T-mediated suppression of LH secretion. Seven pubertal boys (bone age, 11-13.5 yr) were given a control infusion of saline, followed 1 week later by an infusion of T at 960 nmol/m2.h for 41 h starting at 2000 h. During both saline and T infusions, six iv boluses of saline were given hourly beginning at 2400 h on the first day, and six iv boluses of naloxone (0.1 mg/kg each) were given hourly beginning at 2400 h on the second day. Starting at 2200 h, blood was obtained every 15 min for LH and every 30 min for T determinations for 14 h each night. Pituitary responsiveness was assessed at the end of each study night by i.v. bolus administration of 250 ng/kg synthetic GnRH. T infusion increased the mean T concentration 6-fold (P < 0.0001) and suppressed the mean plasma LH concentrations from 5.6 +/- 0.6 to 3.8 +/- 0.6 IU/L (P < 0.01). The nocturnal augmentation of LH secretion was suppressed by the infusion of T, and this suppression was not reversed by naloxone. The mean nighttime plasma LH (2400-0600 h) was 8.1 +/- 1.1 IU/L during the control saline infusion and 5.1 +/- 0.6 IU/L during the T infusion (P < 0.01). The mean LH level was 4.0 +/- 0.7 IU/L during the administration of naloxone boluses concomitantly with the T infusion, not significantly different from that during the T infusion. Likewise, LH pulse frequency during the same time period was decreased by T infusion from 0.6 +/- 0.1 to 0.36 +/- 0.04 pulses/boy.h (P < 0.05), and it was unaltered by coadministration of naloxone (0.38 +/- 0.12 pulses/boy.h). Naloxone administration during the saline infusion did not increase either the mean plasma LH concentration (7.5 +/- 0.7 IU/L; P = NS vs. saline control) or the LH pulse frequency (0.69 +/- 0.1 pulses/boy.h; P = NS vs. saline control). Pituitary responsiveness to GnRH was similar on each of the 4 nights during either saline or T infusions.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2024573923 created "2016-06-24" @default.
• W2024573923 creator A5020447150 @default.
• W2024573923 creator A5030252141 @default.
• W2024573923 creator A5061744780 @default.
• W2024573923 creator A5070604004 @default.
• W2024573923 creator A5075841796 @default.
• W2024573923 creator A5080566750 @default.
• W2024573923 date "1994-10-01" @default.
• W2024573923 modified "2023-09-26" @default.
• W2024573923 title "Nocturnal naloxone fails to reverse the suppressive effects of testosterone infusion on luteinizing hormone secretion in pubertal boys." @default.
• W2024573923 cites W1768846011 @default.
• W2024573923 cites W1964721443 @default.
• W2024573923 cites W1966570620 @default.
• W2024573923 cites W1968183996 @default.
• W2024573923 cites W1980288970 @default.
• W2024573923 cites W1991000644 @default.
• W2024573923 cites W2000618084 @default.
• W2024573923 cites W2002888037 @default.
• W2024573923 cites W2034969500 @default.
• W2024573923 cites W2038501922 @default.
• W2024573923 cites W2040838388 @default.
• W2024573923 cites W2041292994 @default.
• W2024573923 cites W2052551136 @default.
• W2024573923 cites W2060733051 @default.
• W2024573923 cites W2064551313 @default.
• W2024573923 cites W2065369379 @default.
• W2024573923 cites W2069518512 @default.
• W2024573923 cites W2071177566 @default.
• W2024573923 cites W2074831842 @default.
• W2024573923 cites W2078990715 @default.
• W2024573923 cites W2079862587 @default.
• W2024573923 cites W2083227523 @default.
• W2024573923 cites W2094658938 @default.
• W2024573923 cites W2099073664 @default.
• W2024573923 cites W2113626346 @default.
• W2024573923 cites W2142782162 @default.
• W2024573923 cites W2148807607 @default.
• W2024573923 cites W2158892504 @default.
• W2024573923 cites W2166527098 @default.
• W2024573923 cites W2166626056 @default.
• W2024573923 cites W2400760185 @default.
• W2024573923 doi "https://doi.org/10.1210/jcem.79.4.7962287" @default.
• W2024573923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7962287" @default.
• W2024573923 hasPublicationYear "1994" @default.
• W2024573923 type Work @default.
• W2024573923 sameAs 2024573923 @default.
• W2024573923 citedByCount "4" @default.
• W2024573923 crossrefType "journal-article" @default.
• W2024573923 hasAuthorship W2024573923A5020447150 @default.
• W2024573923 hasAuthorship W2024573923A5030252141 @default.
• W2024573923 hasAuthorship W2024573923A5061744780 @default.
• W2024573923 hasAuthorship W2024573923A5070604004 @default.
• W2024573923 hasAuthorship W2024573923A5075841796 @default.
• W2024573923 hasAuthorship W2024573923A5080566750 @default.
• W2024573923 hasConcept C126322002 @default.
• W2024573923 hasConcept C134018914 @default.
• W2024573923 hasConcept C170493617 @default.
• W2024573923 hasConcept C185592680 @default.
• W2024573923 hasConcept C2777334680 @default.
• W2024573923 hasConcept C2777397205 @default.
• W2024573923 hasConcept C2778575703 @default.
• W2024573923 hasConcept C2778750930 @default.
• W2024573923 hasConcept C2778782382 @default.
• W2024573923 hasConcept C2779279991 @default.
• W2024573923 hasConcept C2781063702 @default.
• W2024573923 hasConcept C3017995582 @default.
• W2024573923 hasConcept C43376680 @default.
• W2024573923 hasConcept C71315377 @default.
• W2024573923 hasConcept C71924100 @default.
• W2024573923 hasConceptScore W2024573923C126322002 @default.
• W2024573923 hasConceptScore W2024573923C134018914 @default.
• W2024573923 hasConceptScore W2024573923C170493617 @default.
• W2024573923 hasConceptScore W2024573923C185592680 @default.
• W2024573923 hasConceptScore W2024573923C2777334680 @default.
• W2024573923 hasConceptScore W2024573923C2777397205 @default.
• W2024573923 hasConceptScore W2024573923C2778575703 @default.
• W2024573923 hasConceptScore W2024573923C2778750930 @default.
• W2024573923 hasConceptScore W2024573923C2778782382 @default.
• W2024573923 hasConceptScore W2024573923C2779279991 @default.
• W2024573923 hasConceptScore W2024573923C2781063702 @default.
• W2024573923 hasConceptScore W2024573923C3017995582 @default.
• W2024573923 hasConceptScore W2024573923C43376680 @default.
• W2024573923 hasConceptScore W2024573923C71315377 @default.
• W2024573923 hasConceptScore W2024573923C71924100 @default.
• W2024573923 hasLocation W20245739231 @default.
• W2024573923 hasLocation W20245739232 @default.
• W2024573923 hasOpenAccess W2024573923 @default.
• W2024573923 hasPrimaryLocation W20245739231 @default.
• W2024573923 hasRelatedWork W131746317 @default.
• W2024573923 hasRelatedWork W1964721443 @default.
• W2024573923 hasRelatedWork W1968722289 @default.
• W2024573923 hasRelatedWork W1987063029 @default.
• W2024573923 hasRelatedWork W1994057769 @default.
• W2024573923 hasRelatedWork W2017716624 @default.
• W2024573923 hasRelatedWork W2024573923 @default.
• W2024573923 hasRelatedWork W2025108352 @default.
• W2024573923 hasRelatedWork W2038501922 @default.
• W2024573923 hasRelatedWork W4231822880 @default.
• W2024573923 isParatext "false" @default.

• next