FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024575029> ?p ?o ?g. }

• W2024575029 endingPage "e5134" @default.
• W2024575029 startingPage "e5134" @default.
• W2024575029 abstract "Background Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic interstitial lung disease that is unresponsive to current therapy and often leads to death. However, the rate of disease progression differs among patients. We hypothesized that comparing the gene expression profiles between patients with stable disease and those in which the disease progressed rapidly will lead to biomarker discovery and contribute to the understanding of disease pathogenesis. Methodology and Principal Findings To begin to address this hypothesis, we applied Serial Analysis of Gene Expression (SAGE) to generate lung expression profiles from diagnostic surgical lung biopsies in 6 individuals with relatively stable (or slowly progressive) IPF and 6 individuals with progressive IPF (based on changes in DLCO and FVC over 12 months). Our results indicate that this comprehensive lung IPF SAGE transcriptome is distinct from normal lung tissue and other chronic lung diseases. To identify candidate markers of disease progression, we compared the IPF SAGE profiles in stable and progressive disease, and identified a set of 102 transcripts that were at least 5-fold up regulated and a set of 89 transcripts that were at least 5-fold down regulated in the progressive group (P-value≤0.05). The over expressed genes included surfactant protein A1, two members of the MAPK-EGR-1-HSP70 pathway that regulate cigarette-smoke induced inflammation, and Plunc (palate, lung and nasal epithelium associated), a gene not previously implicated in IPF. Interestingly, 26 of the up regulated genes are also increased in lung adenocarcinomas and have low or no expression in normal lung tissue. More importantly, we defined a SAGE molecular expression signature of 134 transcripts that sufficiently distinguished relatively stable from progressive IPF. Conclusions These findings indicate that molecular signatures from lung parenchyma at the time of diagnosis could prove helpful in predicting the likelihood of disease progression or possibly understanding the biological activity of IPF." @default.
• W2024575029 created "2016-06-24" @default.
• W2024575029 creator A5020872882 @default.
• W2024575029 creator A5036406384 @default.
• W2024575029 creator A5037402194 @default.
• W2024575029 creator A5046641115 @default.
• W2024575029 creator A5047423083 @default.
• W2024575029 creator A5065220890 @default.
• W2024575029 creator A5077607224 @default.
• W2024575029 creator A5082504634 @default.
• W2024575029 creator A5084882531 @default.
• W2024575029 date "2009-04-06" @default.
• W2024575029 modified "2023-10-06" @default.
• W2024575029 title "Molecular Phenotypes Distinguish Patients with Relatively Stable from Progressive Idiopathic Pulmonary Fibrosis (IPF)" @default.
• W2024575029 cites W1486229669 @default.
• W2024575029 cites W1498451757 @default.
• W2024575029 cites W1499343810 @default.
• W2024575029 cites W1583326497 @default.
• W2024575029 cites W1860863518 @default.
• W2024575029 cites W1970379805 @default.
• W2024575029 cites W1982654699 @default.
• W2024575029 cites W1992139042 @default.
• W2024575029 cites W1995801564 @default.
• W2024575029 cites W2000771269 @default.
• W2024575029 cites W2013160251 @default.
• W2024575029 cites W2050076172 @default.
• W2024575029 cites W2069759076 @default.
• W2024575029 cites W2070537009 @default.
• W2024575029 cites W2071438535 @default.
• W2024575029 cites W2072063652 @default.
• W2024575029 cites W2073883677 @default.
• W2024575029 cites W2075408403 @default.
• W2024575029 cites W2075862048 @default.
• W2024575029 cites W2077039635 @default.
• W2024575029 cites W2081200188 @default.
• W2024575029 cites W2085386030 @default.
• W2024575029 cites W2086202147 @default.
• W2024575029 cites W2087159673 @default.
• W2024575029 cites W2095013953 @default.
• W2024575029 cites W2100059970 @default.
• W2024575029 cites W2103229728 @default.
• W2024575029 cites W2104778949 @default.
• W2024575029 cites W2108683967 @default.
• W2024575029 cites W2109974896 @default.
• W2024575029 cites W2110499503 @default.
• W2024575029 cites W2110777286 @default.
• W2024575029 cites W2111223419 @default.
• W2024575029 cites W2117013761 @default.
• W2024575029 cites W2132165198 @default.
• W2024575029 cites W2132334298 @default.
• W2024575029 cites W2136404509 @default.
• W2024575029 cites W2137064182 @default.
• W2024575029 cites W2140683239 @default.
• W2024575029 cites W2143191365 @default.
• W2024575029 cites W2143491429 @default.
• W2024575029 cites W2144310026 @default.
• W2024575029 cites W2145009320 @default.
• W2024575029 cites W2148077790 @default.
• W2024575029 cites W2148714608 @default.
• W2024575029 cites W2149477903 @default.
• W2024575029 cites W2150926065 @default.
• W2024575029 cites W2154976095 @default.
• W2024575029 cites W2160639837 @default.
• W2024575029 cites W2416914730 @default.
• W2024575029 cites W3023255269 @default.
• W2024575029 cites W4211009571 @default.
• W2024575029 cites W4213387068 @default.
• W2024575029 doi "https://doi.org/10.1371/journal.pone.0005134" @default.
• W2024575029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2661376" @default.
• W2024575029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19347046" @default.
• W2024575029 hasPublicationYear "2009" @default.
• W2024575029 type Work @default.
• W2024575029 sameAs 2024575029 @default.
• W2024575029 citedByCount "166" @default.
• W2024575029 countsByYear W20245750292012 @default.
• W2024575029 countsByYear W20245750292013 @default.
• W2024575029 countsByYear W20245750292014 @default.
• W2024575029 countsByYear W20245750292015 @default.
• W2024575029 countsByYear W20245750292016 @default.
• W2024575029 countsByYear W20245750292017 @default.
• W2024575029 countsByYear W20245750292018 @default.
• W2024575029 countsByYear W20245750292019 @default.
• W2024575029 countsByYear W20245750292020 @default.
• W2024575029 countsByYear W20245750292021 @default.
• W2024575029 countsByYear W20245750292022 @default.
• W2024575029 countsByYear W20245750292023 @default.
• W2024575029 crossrefType "journal-article" @default.
• W2024575029 hasAuthorship W2024575029A5020872882 @default.
• W2024575029 hasAuthorship W2024575029A5036406384 @default.
• W2024575029 hasAuthorship W2024575029A5037402194 @default.
• W2024575029 hasAuthorship W2024575029A5046641115 @default.
• W2024575029 hasAuthorship W2024575029A5047423083 @default.
• W2024575029 hasAuthorship W2024575029A5065220890 @default.
• W2024575029 hasAuthorship W2024575029A5077607224 @default.
• W2024575029 hasAuthorship W2024575029A5082504634 @default.
• W2024575029 hasAuthorship W2024575029A5084882531 @default.
• W2024575029 hasBestOaLocation W20245750291 @default.
• W2024575029 hasConcept C104317684 @default.

• next