FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024576325> ?p ?o ?g. }

• W2024576325 abstract "Background Gamma-aminobutyric acid-A (GABA-A) receptors, the major inhibitory neurotransmitter receptors in the brain are implicated in the acute and chronic effects of alcohol, including tolerance, dependence and withdrawal. Various polymorphisms in the gene encoding the GABA-A receptor alpha2 subunit (GABRA2) have been associated with alcoholism and with antisocial behavior in different populations of European ancestry. As early onset of alcoholism often reflects greater severity, including a higher risk for recurrence, comorbid antisocial personality disorder and conduct disorder, Cloninger’s classification distinguishes type II alcoholism with an early onset, elevated levels of antisocial behavior and delinquency, from the type I alcoholism with a late onset, neurotic symptoms and minimal criminality. Materials and methods Genotyping of GABRA2 polymorphisms (rs567926, rs279858 and rs9291283) was performed in samples of 355 alcoholic patients of Croatian origin (280 males and 75 females) using TaqMan Real-Time allelic discrimination technique after extraction of DNA from the whole blood. The results of allelic and haplotypic analysis were compared between alcohol-dependent subjects with a combination of early onset of alcohol abuse and presence of aggressive behavior corresponding to type II alcoholism subgroup, and individuals with the late onset of alcohol abuse and without aggression corresponding to type I alcoholism subgroup, according to Cloninger. Results Cloninger’s Type I and Type II alcohol-dependent patients did not differ significantly in the frequency of the genotypes and alleles for rs567926, rs279858 or rs9291283. However, the G-T- G haplotype was more often present in the alcohol- dependent subjects with early onset of alcohol abuse and aggressive behavior, corresponding to the Cloninger type II alcoholism subgroup (χ2 = 6.102, p = 0.013). Conclusions Our results revealed a haplotypic association between the GABRA2 gene and a more severe form of alcoholism, characterized by the early onset of alcohol abuse and presence of aggressive behavior. These findings support an important role of GABA-A receptors in the susceptibility to alcoholism and highlight them as potential targets for novel therapeutics in the treatment of alcohol dependence." @default.
• W2024576325 created "2016-06-24" @default.
• W2024576325 creator A5001894090 @default.
• W2024576325 creator A5005465511 @default.
• W2024576325 creator A5017563111 @default.
• W2024576325 creator A5077955716 @default.
• W2024576325 creator A5089261581 @default.
• W2024576325 creator A5089502676 @default.
• W2024576325 date "2012-09-01" @default.
• W2024576325 modified "2023-10-08" @default.
• W2024576325 title "The GABAAreceptor α2 subunit gene (GABRA2) is associated with alcohol-related behavior" @default.
• W2024576325 doi "https://doi.org/10.1186/2050-6511-13-s1-a8" @default.
• W2024576325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3506347" @default.
• W2024576325 hasPublicationYear "2012" @default.
• W2024576325 type Work @default.
• W2024576325 sameAs 2024576325 @default.
• W2024576325 citedByCount "1" @default.
• W2024576325 countsByYear W20245763252020 @default.
• W2024576325 crossrefType "journal-article" @default.
• W2024576325 hasAuthorship W2024576325A5001894090 @default.
• W2024576325 hasAuthorship W2024576325A5005465511 @default.
• W2024576325 hasAuthorship W2024576325A5017563111 @default.
• W2024576325 hasAuthorship W2024576325A5077955716 @default.
• W2024576325 hasAuthorship W2024576325A5089261581 @default.
• W2024576325 hasAuthorship W2024576325A5089502676 @default.
• W2024576325 hasBestOaLocation W20245763251 @default.
• W2024576325 hasConcept C104292427 @default.
• W2024576325 hasConcept C104317684 @default.
• W2024576325 hasConcept C2781066024 @default.
• W2024576325 hasConcept C54355233 @default.
• W2024576325 hasConcept C55493867 @default.
• W2024576325 hasConcept C556039675 @default.
• W2024576325 hasConcept C60644358 @default.
• W2024576325 hasConcept C70721500 @default.
• W2024576325 hasConcept C71924100 @default.
• W2024576325 hasConcept C86803240 @default.
• W2024576325 hasConcept C98274493 @default.
• W2024576325 hasConceptScore W2024576325C104292427 @default.
• W2024576325 hasConceptScore W2024576325C104317684 @default.
• W2024576325 hasConceptScore W2024576325C2781066024 @default.
• W2024576325 hasConceptScore W2024576325C54355233 @default.
• W2024576325 hasConceptScore W2024576325C55493867 @default.
• W2024576325 hasConceptScore W2024576325C556039675 @default.
• W2024576325 hasConceptScore W2024576325C60644358 @default.
• W2024576325 hasConceptScore W2024576325C70721500 @default.
• W2024576325 hasConceptScore W2024576325C71924100 @default.
• W2024576325 hasConceptScore W2024576325C86803240 @default.
• W2024576325 hasConceptScore W2024576325C98274493 @default.
• W2024576325 hasIssue "S1" @default.
• W2024576325 hasLocation W20245763251 @default.
• W2024576325 hasLocation W20245763252 @default.
• W2024576325 hasOpenAccess W2024576325 @default.
• W2024576325 hasPrimaryLocation W20245763251 @default.
• W2024576325 hasRelatedWork W138759245 @default.
• W2024576325 hasRelatedWork W148154650 @default.
• W2024576325 hasRelatedWork W1969572685 @default.
• W2024576325 hasRelatedWork W2002978144 @default.
• W2024576325 hasRelatedWork W2015520977 @default.
• W2024576325 hasRelatedWork W2413472917 @default.
• W2024576325 hasRelatedWork W2837554060 @default.
• W2024576325 hasRelatedWork W3135711742 @default.
• W2024576325 hasRelatedWork W3168066705 @default.
• W2024576325 hasRelatedWork W4306632516 @default.
• W2024576325 hasVolume "13" @default.
• W2024576325 isParatext "false" @default.
• W2024576325 isRetracted "false" @default.
• W2024576325 magId "2024576325" @default.
• W2024576325 workType "article" @default.