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- W2024576502 abstract "To compare the pharmacokinetics and pharmacodynamics of 100 mg/d, 200 mg/d, and 400 mg/d (200 mg two times per day) of P administered vaginally for 14 days to estrogen-primed postmenopausal women.Randomized, open-label, three-way crossover study.Two university-based investigative sites.Twenty healthy postmenopausal women with histologically normal endometria.Oral 17 beta-E2 was given each day of a 28-day cycle; a P vaginal suppository was inserted daily according to the randomization schedule during days 15-28 of each cycle; blood samples were collected; an endometrial biopsy was obtained on day 25; and patients were crossed over to the next treatment cycle after a washout period of at least 30 days.Mean P blood levels, endometrial dating/conversion.There was good vaginal absorption of P for all dosages. Endometrial conversion occurred in all 200- and 400-mg/d P-dosed cycles, whereas the 100-mg/d dosage failed to convert primed endometria consistently. There also was a significantly increased tendency for earlier bleeding and spotting with the 100-mg/d dosage.Both the 200- and 400-mg/d dosage regimens consistently convert an estrogen-primed endometrium, and yield appropriate endometrial dating and bleeding patterns. However, the 400-mg/d dosage attains the highest sustained blood levels and may be the best dosage regimen for further study." @default.
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- W2024576502 title "Peripheral progesterone (P) levels and endometrial response to various dosages of vaginally administered P in estrogen-primed women" @default.
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- W2024576502 doi "https://doi.org/10.1016/s0015-0282(97)00329-4" @default.
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