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- W2024578614 endingPage "654" @default.
- W2024578614 startingPage "638" @default.
- W2024578614 abstract "mTOR (the mechanistic target of rapamycin) is an atypical serine/threonine kinase involved in regulating major cellular functions including growth and proliferation. Deregulation of the mTOR signaling pathway is one of the most commonly observed pathological alterations in human cancers. To this end, oncogenic activation of the mTOR signaling pathway contributes to cancer cell growth, proliferation and survival, highlighting the potential for targeting the oncogenic mTOR pathway members as an effective anti-cancer strategy. In order to do so, a thorough understanding of the physiological roles of key mTOR signaling pathway components and upstream regulators would guide future targeted therapies. Thus, in this review, we summarize available genetic mouse models for mTORC1 and mTORC2 components, as well as characterized mTOR upstream regulators and downstream targets, and assign a potential oncogenic or tumor suppressive role for each evaluated molecule. Together, our work will not only facilitate the current understanding of mTOR biology and possible future research directions, but more importantly, provide a molecular basis for targeted therapies aiming at key oncogenic members along the mTOR signaling pathway." @default.
- W2024578614 created "2016-06-24" @default.
- W2024578614 creator A5005394879 @default.
- W2024578614 creator A5067992967 @default.
- W2024578614 creator A5071663193 @default.
- W2024578614 date "2014-12-01" @default.
- W2024578614 modified "2023-10-18" @default.
- W2024578614 title "mTOR signaling in tumorigenesis" @default.
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