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- W2024579845 abstract "Rainbow trout held at 6.5°C were fed food supplemented with 12 ppm T3 (3,5,3′-triiodo-L-thyronine). By 2 weeks, plasma T3 had increased from 3.7 ng/ml (controls) to 12 ng/ml and stayed at that level for 12 weeks with minor change in plasma L-thyroxine (T4). The hepatic microsomal 5′-deiodinase (5′-D) activity (Vmax fell to 25% of control values by 2 weeks and by 12 weeks was undetectable. Trout were also fed the T3-supplemented food for 6 weeks and then reverted to control food (0 ppm T3) for 6 weeks. After 2 weeks reversion, plasma T3 was 48% lower and 5′-D Vmax 78% lower than for control fish fed 0 ppm T3 throughout; after 6 weeks reversion, plasma T3 had recovered, but 5′-D had regained only 58% of control values. These data confirm that exogenous T3 suppresses endogenous T3 production and suggest extrathyroidal autoregulation of T3 production. Furthermore, even 6 weeks after T3 treatment had ceased, hepatic 5′-D was subnormal, indicating development of T3 dependency." @default.
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- W2024579845 date "1991-02-01" @default.
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- W2024579845 title "Response of hepatic thyroxine 5′-deiodinase of rainbow trout,Oncorhynchus mykiss, to chronic ingestion of 3,5,3′-triiodo-L-thyronine" @default.
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- W2024579845 doi "https://doi.org/10.1002/jez.1402570213" @default.
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